ArticleMammalian genome : official journal of the International Mammalian Genome Society1998
Identification of quantitative trait loci for prolificacy and growth in mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Comparison of commonly used ICR stocks and the characterization of Korl:ICR.Laboratory animal research · 2017Article
- Genetics of Rapid and Extreme Size Evolution in Island Mice.Genetics · 2015Article
- A Major Gene for Bovine Ovulation Rate.PloS one · 2015Article
- An integrative genomic analysis of the superior fecundity phenotype in QSi5 mice.Molecular biotechnology · 2013Article
- Mapping interacting QTL for count phenotypes using hierarchical Poisson and binomial models: an application to reproductive traits in mice.Genetics research · 2010Article
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- Quantitative trait loci for body weight, condition factor and age at sexual maturation in Arctic charr (Salvelinus alpinus): comparative analysis with rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar).Molecular genetics and genomics : MGG · 2007Article
- Identification of genetic regions of importance for reproductive performance in female mice.Genetics · 2006Article
- Relationships between quantitative and reproductive fitness traits in animals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- Development of a highly fecund inbred strain of mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- A large-sample QTL study in mice: III. Reproduction.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- A large-sample QTL study in mice: I. Growth.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
- Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice.Genome research · 2000Article
- Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth.Genetics · 1998Article
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4 authors.
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Abstract
Marker-quantitative trait locus (QTL) linkage was evaluated in F2 intercross and backcross mouse populations derived from stocks differing dramatically in prolificacy and mature weight. A highly prolific outbred Quackenbush-Swiss mouse line, or an inbred line derived from it (16.62 +/- 0.22 and 14.64 +/- 0.27 pups per litter, respectively) were used as one of the grandparents in these populations. The less prolific C57BL/6J inbred mouse line (6.67 +/- 0.37 pups per litter) was used as the other grandparent. Linkage was evaluated in a three-step process that involved selective genotyping of F2 intercross progeny representing extremes for prolificacy, genotyping of the full F2 for chromosomal regions potentially associated with prolificacy, and genotyping of the backcross for genomic regions significantly associated with prolificacy in the F2. Segments of Chromosomes (Chrs) 2 and 4 were significantly (P < 0.05, experiment-wise error rate) associated with prolificacy, and LOD scores suggestive of linkage were observed for litter size on Chr 9 and growth on Chrs 4 and 11. Existence of growth QTL was also supported by marker effects that were significant (P < 0.05) or approaching significance (P < 0.10) in the backcross. Additive litter size QTL effects ranged from 0.56 to 0.79 pups per litter, and dominance deviations ranged from -0.56 to 1.19 pups per litter, suggesting overdominance as a possible mode of gene action in some cases. The observation of pleiotropic or linked QTL for growth and prolificacy corresponds well with results from many selection experiments identifying positively correlated responses to selection for these two traits.
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