ArticleThe Journal of cell biology1998
Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Translationally Controlled Tumor Protein (TCTP) and Growth Regulation in the Drosophila Model.Advances in experimental medicine and biology · 2025Article
- A single cell RNA sequence atlas of the early Drosophila larval eye.BMC genomics · 2024Article
- Super-resolution microscopy reveals stochastic initiation of replication in Drosophila polytene chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Article
- Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.The Journal of biological chemistry · 2015Article
- Regulating DNA replication in eukarya.Cold Spring Harbor perspectives in biology · 2013Review
- Safeguarding genetic information in Drosophila.Chromosoma · 2011Review
- Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression.BMC molecular biology · 2011Article
- Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells.Nucleic acids research · 2011Article
- Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells.Journal of cell science · 2010Article
- Dosage-sensitive regulation of cohesin chromosome binding and dynamics by Nipped-B, Pds5, and Wapl.Molecular and cellular biology · 2010Article
- Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro.Journal of cell science · 2010Article
- Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer.Cell division · 2010Article
- Endoreplication: polyploidy with purpose.Genes & development · 2009Review
- Endocycling cells do not apoptose in response to DNA rereplication genotoxic stress.Genes & development · 2008Article
- Preventing re-replication of chromosomal DNA.Nature reviews. Molecular cell biology · 2005Review
- Review
- Cyclin E in normal and neoplastic cell cycles.Oncogene · 2005Review
- DNA replication and progression through S phase.Oncogene · 2005Review
- The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles.The EMBO journal · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Minichromosome maintenance (MCM) proteins are essential eukaryotic DNA replication factors. The binding of MCMs to chromatin oscillates in conjunction with progress through the mitotic cell cycle. This oscillation is thought to play an important role in coupling DNA replication to mitosis and limiting chromosome duplication to once per cell cycle. The coupling of DNA replication to mitosis is absent in Drosophila endoreplication cycles (endocycles), during which discrete rounds of chromosome duplication occur without intervening mitoses. We examined the behavior of MCM proteins in endoreplicating larval salivary glands, to determine whether oscillation of MCM-chromosome localization occurs in conjunction with passage through an endocycle S phase. We found that MCMs in polytene nuclei exist in two states: associated with or dissociated from chromosomes. We demonstrate that cyclin E can drive chromosome association of DmMCM2 and that DNA synthesis erases this association. We conclude that mitosis is not required for oscillations in chromosome binding of MCMs and propose that cycles of MCM-chromosome association normally occur in endocycles. These results are discussed in a model in which the cycle of MCM-chromosome associations is uncoupled from mitosis because of the distinctive program of cyclin expression in endocycles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.