ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Organization and reorganization of neuromuscular junctions in mice lacking neural cell adhesion molecule, tenascin-C, or fibroblast growth factor-5.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Molecular and Regenerative Characterization of Repair and Non-repair Schwann Cells.Cellular and molecular neurobiology · 2023Article
- FGF5 Regulates Schwann Cell Migration and Adhesion.Frontiers in cellular neuroscience · 2020Article
- Nerve, Muscle, and Synaptogenesis.Cells · 2019Review
- Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters.Scientific reports · 2018Article
- Perspectives in Diagnosis and Treatment of Rabies Viral Encephalitis: Insights from Pathogenesis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5.Scientific reports · 2016Article
- Polyclonal neural cell adhesion molecule antibody prolongs the effective duration time of botulinum toxin in decreasing muscle strength.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
- Presynaptic NCAM is required for motor neurons to functionally expand their peripheral field of innervation in partially denervated muscles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A stem-cell based bioassay to critically assess the pathology of dysfunctional neuromuscular junctions.PloS one · 2014Article
- Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons.The Journal of biological chemistry · 2013Article
- Role of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junction.Developmental neurobiology · 2011Review
- Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation.PloS one · 2010Article
- Activity of nAChRs containing alpha9 subunits modulates synapse stabilization via bidirectional signaling programs.Developmental neurobiology · 2009Article
- Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Focal adhesion kinase signaling regulates the expression of caveolin 3 and beta1 integrin, genes essential for normal myoblast fusion.Molecular biology of the cell · 2009Article
- A novel role for embigin to promote sprouting of motor nerve terminals at the neuromuscular junction.The Journal of biological chemistry · 2009Article
- Ciliary neurotrophic factor is not required for terminal sprouting and compensatory reinnervation of neuromuscular synapses: re-evaluation of CNTF null mice.Experimental neurology · 2007Article
- Plasticity of neuromuscular junction architectures in rat slow and fast muscle fibers following temporary denervation and reinnervation processes.Journal of muscle research and cell motility · 2006Article
- Developmental changes in the neuronal protein composition: a study by high resolution 2D-gel electrophoresis.Molecular and cellular biochemistry · 2005Article
- Polysialylated neural cell adhesion molecule is necessary for selective targeting of regenerating motor neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many proteins have been hypothesized to mediate intercellular interactions that regulate the formation, maturation, and maintenance of the skeletal neuromuscular junction. Three of the best characterized of these are a membrane-associated adhesion molecule, neural cell adhesion molecule (N-CAM), an extracellular matrix component, tenascin-C, and a soluble growth factor, fibroblast growth factor-5 (FGF-5). To assess the roles of these molecules in synaptogenesis in vivo, we examined neuromuscular junctions in homozygous mutant mice lacking N-CAM, tenascin-C, FGF-5, or both N-CAM and tenascin-C. End plates were 14% smaller in N-CAM-deficient mice than in controls, and formation of junctional folds was delayed in this mutant. In all other respects tested, however, the structure and molecular architecture of neuromuscular junctions were normal in all three single mutants and in the double mutant. We also tested the abilities of damaged motor axons to reinnervate mutant muscle after axotomy and of intact motor axons to sprout after partial denervation. Again, no significant differences among genotypes were observed. Together, these results demonstrate that N-CAM, tenascin-C, and FGF-5 are dispensable for major aspects of synaptic development and regeneration.
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