ArticleInfection and immunity1998
Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a DNA-monophosphoryl lipid A adjuvant vaccine.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 79 citations in OpenAlex.
- An Update on the HIV DNA Vaccine Strategy.Vaccines · 2021Review
- Nasal aluminum (oxy)hydroxide enables adsorbed antigens to induce specific systemic and mucosal immune responses.Human vaccines & immunotherapeutics · 2017Article
- Comparative analysis of routes of immunization of a live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in a heterologous virus challenge study.Veterinary research · 2016Article
- Synthetic DNA vaccine strategies against persistent viral infections.Expert review of vaccines · 2013Review
- Induction of T helper 1 response by immunization of BALB/c mice with the gene encoding the second subunit of Echinococcus granulosus antigen B (EgAgB8/2).Parasite (Paris, France) · 2012Article
- Modulation of γδ T cell responses by TLR ligands.Cellular and molecular life sciences : CMLS · 2011Review
- Ultrasonic synthetic technique to manufacture a pHEMA nanopolymeric-based vaccine against the H6N2 avian influenza virus: a preliminary investigation.International journal of nanomedicine · 2011Article
- Mucosal adjuvanticity of a Shigella invasin complex with dna-based vaccines.Clinical and vaccine immunology : CVI · 2009Article
- Article
- Mucosal immunity: overcoming the barrier for induction of proximal responses.Immunologic research · 2004Review
- Mechanisms of monophosphoryl lipid A augmentation of host responses to recombinant HagB from Porphyromonas gingivalis.Infection and immunity · 2002Article
- Improved tuberculosis DNA vaccines by formulation in cationic lipids.Infection and immunity · 2002Article
- Nucleic acid vaccines: tasks and tactics.Immunologic research · 2001Review
- Adjuvant activity of monophosphoryl lipid A for nasal and oral immunization with soluble or liposome-associated antigen.Infection and immunity · 2000Article
- The role of CpG in DNA vaccines.Springer seminars in immunopathology · 2000Review
- Nasal immunization of mice with human papillomavirus type 16 (HPV-16) virus-like particles or with the HPV-16 L1 gene elicits specific cytotoxic T lymphocytes in vaginal draining lymph nodes.Journal of virology · 1999Article
- Mucosal immunity and tolerance: relevance to vaccine development.Immunological reviews · 1999Review
- Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates.Molecular medicine (Cambridge, Mass.) · 1999Article
- Induction of systemic and mucosal immune responses to human immunodeficiency virus type 1 by a DNA vaccine formulated with QS-21 saponin adjuvant via intramuscular and intranasal routes.Journal of virology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compared immune responses to intranasal and intramuscular DNA vaccinations against human immunodeficiency virus type 1 with monophosphoryl lipid A (MPL) used as an adjuvant. Both routes of vaccination resulted in similar levels of cell-mediated immunity, but the intestinal secretory immunoglobulin A response was higher following intranasal immunization than after intramuscular immunization. MPL demonstrated its adjuvanticity in vaccination by both routes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.