ArticleInfection and immunity1998
Proteolytic activation of the interleukin-1beta precursor by Candida albicans.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 72 citations in OpenAlex.
- More than Just Protein Degradation: The Regulatory Roles and Moonlighting Functions of Extracellular Proteases Produced by Fungi Pathogenic for Humans.Journal of fungi (Basel, Switzerland) · 2023Review
- Cathepsin L3 FromFrontiers in immunology · 2019Article
- NLRP3-Dependent and -Independent Processing of Interleukin (IL)-1β in Active Ulcerative Colitis.International journal of molecular sciences · 2018Article
- Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33.Nature immunology · 2018Article
- Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage.Scientific reports · 2018Article
- Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production.Scientific reports · 2016Article
- Immune defence against Candida fungal infections.Nature reviews. Immunology · 2015Review
- Inflammasome/IL-1β Responses to Streptococcal Pathogens.Frontiers in immunology · 2015Review
- TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung.Respiratory research · 2014Article
- Pathways of IL-1β secretion by macrophages infected with clinical Mycobacterium tuberculosis strains.Tuberculosis (Edinburgh, Scotland) · 2013Article
- Article
- Understanding the mechanism of IL-1β secretion.Cytokine & growth factor reviews · 2011Review
- Evaluation of antifungal activity of medicinal plant extracts against oral Candida albicans and proteinases.Mycopathologia · 2011Article
- IL-1beta processing in host defense: beyond the inflammasomes.PLoS pathogens · 2010Review
- Basidiomycete metabolites attenuate virulence properties of Candida albicans in vitro.Mycoses · 2008Article
- Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis.Infection and immunity · 2005Article
- Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection.Clinical microbiology reviews · 2004Review
- Candida albicans secreted aspartyl proteinases in virulence and pathogenesis.Microbiology and molecular biology reviews : MMBR · 2003Review
- Interleukin-18 and gamma interferon production by oral epithelial cells in response to exposure to Candida albicans or lipopolysaccharide stimulation.Infection and immunity · 2002Article
- Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice.Infection and immunity · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic inflammation rather than invasion is characteristic of some forms of superficial candidiasis such as denture stomatitis. We hypothesized that Candida albicans may play a critical role in the pathogenesis of inflammatory lesions observed in chronic candidiasis by activating the proinflammatory cytokine interleukin-1beta (IL-1beta) from epithelial stores of the precursor. The aim of this study was therefore to demonstrate the proteolytic cleavage and activation of the inactive precursor of IL-1beta (pro-IL-1beta) by C. albicans. After incubation of either blastospores or hyphae with the inactive precursor, proteolytic cleavage was monitored by sodium dodecyl sulfate-polyacrylamide gel electrophoresis Western immunoblotting analysis, and the biological activity of the cleavage products was tested in a bioassay. We report here that late-stationary-growth-phase blastospores as well as hyphae of C. albicans, but not exponentially growing cells, can efficiently cleave pro-IL-1beta to yield fragments of molecular masses compatible with mature biologically active IL-1beta (17 to 19 kDa). Assays conducted in the presence of selected proteinase inhibitors suggest that the cleavage of pro-IL-1beta involves the participation of one or more aspartyl proteinases. Cleavage products showed a dose-dependent IL-1beta-like activity in a thymocyte proliferation bioassay, which was inhibited by anti-IL-1beta neutralizing antibodies. The present data thus suggest a role for C. albicans proteinases in the activation and maintenance of the inflammatory response at epithelial surfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.