ArticleInfection and immunity1998
Activation of bovine lymphocyte subpopulations by staphylococcal enterotoxin C.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 77 citations in OpenAlex.
- Prevalence and antibiogram profiling of enterotoxigenic methicillin-resistantIranian journal of veterinary research · 2025Article
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- Prevalence and characterization of Staphylococcus aureus isolated in raw milk from cows in Hokkaido, Japan.Tropical animal health and production · 2020Article
- Profiles of Staphyloccocus aureus isolated from goat persistent mastitis before and after treatment with enrofloxacin.BMC microbiology · 2020Article
- Molecular Characterization ofFrontiers in microbiology · 2017Article
- Genotypic characterization of Staphylococcus aureus isolated from bovines, humans, and food in Indonesia.Journal of veterinary science · 2011Article
- Involvement of immune response in anti-tumor effects of Staphylococcus aureus filtrate preparation.Journal of cancer research and clinical oncology · 2008Article
- Long-term staphylococcal enterotoxin C1 exposure induces soluble factor-mediated immunosuppression by bovine CD4+ and CD8+ T cells.Infection and immunity · 2007Article
- Unique features of bovine lymphocytes exposed to a staphylococcal enterotoxin.Journal of veterinary science · 2006Article
- Staphylococcus aureus enterotoxin D is secreted in milk and stimulates specific antibody responses in cows in the course of experimental intramammary infection.Infection and immunity · 2006Article
- Cytotoxin and pyrogenic toxin superantigen gene profiles of Staphylococcus aureus associated with subclinical mastitis in dairy cows and relationships with macrorestriction genomic profiles.Journal of clinical microbiology · 2005Article
- A mutant of staphylococcal enterotoxin C devoid of bacterial superantigenic activity elicits a Th2 immune response for protection against Staphylococcus aureus infection.Infection and immunity · 2005Article
- Induction of nitric oxide production mediated by tumor necrosis factor alpha on staphylococcal enterotoxin C-stimulated bovine mammary gland cells.Clinical and diagnostic laboratory immunology · 2004Article
- Inflammatory responses of bovine polymorphonuclear neutrophils induced by staphylococcal enterotoxin C via stimulation of mononuclear cells.Clinical and diagnostic laboratory immunology · 2003Article
- Identity of activation molecule 3 on superantigen-stimulated bovine cells is CD26.Infection and immunity · 2001Article
- Toxin genes and other characteristics of Staphylococcus aureus isolates from milk of cows with mastitis.Clinical and diagnostic laboratory immunology · 2001Article
- Glyceraldehyde-3-phosphate dehydrogenase-encoding gene as a useful taxonomic tool for Staphylococcus spp.Journal of clinical microbiology · 2000Article
- Antiviral activity of shiga toxin 1: suppression of bovine leukemia virus-related spontaneous lymphocyte proliferation.Infection and immunity · 2000Article
- Selective recruitment of T-cell subsets to the udder during staphylococcal and streptococcal mastitis: analysis of lymphocyte subsets and adhesion molecule expression.Infection and immunity · 1999Article
- Rapid identification and typing of Staphylococcus aureus by PCR-restriction fragment length polymorphism analysis of the aroA gene.Journal of clinical microbiology · 1999Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Staphylococcus aureus is a major mastitis-causing pathogen in cattle. The chronic nature of bovine staphylococcal mastitis suggests that some products or components of S. aureus may interfere with the development of protective immunity. One class of molecules that could be involved are superantigens (SAgs). Although a significant number of mastitis isolates produce SAgs, the effect of these molecules on the bovine immune system is unresolved. To determine if immunosuppression caused by SAgs could play a role in pathogenesis, we monitored bovine lymphocytes exposed to staphylococcal enterotoxin C1 (SEC1). Activation of bovine lymphocytes by either SEC1 or concanavalin A (ConA) was influenced by the gammadelta/alphabeta T-cell ratio in the culture. Compared to ConA-induced stimulation, cultures stimulated with SEC1 generated small numbers of CD4+ alphabeta T cells expressing high levels of interleukin-2 receptor alpha chain (IL-2R alpha) and major histocompatibility complex class II (MHCII), suggesting that SAg exposure does not lead to full activation of these cells. This state of partial activation was most pronounced in cultures with a high gammadelta/alphabeta ratio. In contrast, significant numbers of CD8+ alphabeta T cells expressed high levels of IL-2R alpha and MHCII, regardless of the gammadelta/alphabeta ratio and the stimulant used. CD8+ blasts in cultures stimulated with SEC1 also expressed another activation marker, ACT3, previously detected predominantly on thymocytes and CD4+ T cells. Although gammadelta CD2- and CD2+ T cells expressed MHCII and IL-2R alpha following stimulation with SEC1, only a few cells increased to blast size, suggesting that they were only partially activated. The results suggest ways in which SAgs might facilitate immunosuppression that promotes the persistence of bacteria in cattle and contributes to chronic intramammary infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.