ArticleBMJ (Clinical research ed.)1998
Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study.
Article in BMJ (Clinical research ed.), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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51 citing papers in PubMed, 1 synthesis or guideline pooled it, 403 citations in OpenAlex.
- Guideline
- Prevention of symptomatic pulmonary embolism for gynecologic malignancies with preoperative asymptomatic venous thromboembolism: GOTIC-VTE trial.Journal of gynecologic oncology · 2024Trial
- Resident performed two-point compression ultrasound is inadequate for diagnosis of deep vein thrombosis in the critically III.Journal of thrombosis and thrombolysis · 2014Trial
- Safety of withholding anticoagulation in pregnant women with suspected deep vein thrombosis following negative serial compression ultrasound and iliac vein imaging.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2013Trial
- The Anticoagulation of Calf Thrombosis (ACT) project: study protocol for a randomized controlled trial.Trials · 2012Trial
- Incidence of lower limbs deep vein thrombosis after open and laparoscopic gastric bypass: a prospective study.Obesity surgery · 2008Trial
- Evaluation of the Simplify D-dimer assay as a screening test for the diagnosis of deep vein thrombosis in an emergency department.Emergency medicine journal : EMJ · 2004Trial
- An algorithm for the investigation and management of patients with suspected deep venous thrombosis at a district general hospital.Postgraduate medical journal · 2002Trial
- D-dimer testing as an adjunct to ultrasonography in patients with clinically suspected deep vein thrombosis: prospective cohort study. The Multicentre Italian D-dimer Ultrasound Study Investigators Group.BMJ (Clinical research ed.) · 1998Trial
- Preoperative prevalence and risk factors for thromboembolic events following tibial plateau fractures: a retrospective analysis of an underestimated risk.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Platelet count, fibrinogen and ROTEM® parameters predict deep vein thrombosis in elderly patients with femoral fracture.Journal of anesthesia, analgesia and critical care · 2026Article
- Para-Aortic Lymph Node Dissection and Metastasis Increase the Rate of Postoperative VTE in Gynaecological Cancers.Cancers · 2025Article
- Nomogram-based prediction of the prognosis in patients with free floating venous thrombus after closed traumatic fracture.BMC medical imaging · 2025Article
- Expert-Based Narrative Review on Compression UltraSonography (CUS) for Diagnosis and Follow-Up of Deep Venous Thrombosis (DVT).Diagnostics (Basel, Switzerland) · 2025Review
- Profile of Patients with Isolated Distal Deep Vein Thrombosis versus Proximal Deep Vein Thrombosis or Pulmonary Embolism: RE-COVERY DVT/PE Study.Seminars in thrombosis and hemostasis · 2022Observational
- Joint Guideline on Venous Thromboembolism - 2022.Arquivos brasileiros de cardiologia · 2022Article
- Isolated calf deep venous thrombosis: frequency on venous ultrasound and clinical characteristics.BMC emergency medicine · 2021Article
- Incidence and locations of preoperative deep venous thrombosis (DVT) of lower extremity following tibial plateau fractures: a prospective cohort study.Journal of orthopaedic surgery and research · 2021Article
- Incidence and locations of deep venous thrombosis of the lower extremity following surgeries of tibial plateau fractures: a prospective cohort study.Journal of orthopaedic surgery and research · 2020Article
- How to screen and diagnose deep venous thrombosis (DVT) in patients hospitalized for or suspected of COVID-19 infection, outside the intensive care units.Journal de medecine vasculaire · 2020Review
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the safety of withholding anticoagulant treatment from patients with clinically suspected deep vein thrombosis but normal findings on compression ultrasonography.
designCompression ultrasonography was done with a simplified diagnostic procedure limited to the common femoral vein in the groin and the popliteal vein extending down to the trifurcation of the calf veins. Patients with normal ultrasonography findings at presentation were retested 1 week later.
main outcome measureThe incidence of venous thromboembolic complications during follow up for 6 months in patients in whom anticoagulant treatment was withheld on the basis of normal results on two ultrasonography tests 1 week apart.
settingUniversity research centres in four hospitals.
resultsA total of 1702 patients were included in the study. Abnormal results on compression ultrasonography at presentation or at 1 week were found in 400 and 12 patients, respectively, for a prevalence of deep vein thrombosis of 24%. None of the patients were lost to follow up. Venous thromboembolic complications during the week of serial testing occurred in a single patient and in eight patients during 6 months' follow up, resulting in a cumulative rate of venous thromboembolic complications of 0.7% (95% confidence interval 0.3% to 1.2%). The mean number of extra hospital visits and additional tests required per initially referred patient was 0.8.
conclusionIt is safe to withhold anticoagulant treatment from patients with clinically suspected deep vein thrombosis who have a normal result on compression ultrasonography at the time of presentation and at 1 week.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.