ArticleThe EMBO journal1998
Pankinetoplast DNA structure in a primitive bodonid flagellate, Cryptobia helicis.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Mitochondrial RNA editing inComputational and structural biotechnology journal · 2022Article
- Euglenozoa: taxonomy, diversity and ecology, symbioses and viruses.Open biology · 2021Review
- Novel organization of mitochondrial minicircles and guide RNAs in the zoonotic pathogen Trypanosoma lewisi.Nucleic acids research · 2020Article
- Article
- Orientation of DNA Minicircles Balances Density and Topological Complexity in Kinetoplast DNA.PloS one · 2015Article
- Systematically fragmented genes in a multipartite mitochondrial genome.Nucleic acids research · 2011Article
- Organization and expression of organellar genomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Cascades of convergent evolution: the corresponding evolutionary histories of euglenozoans and dinoflagellates.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Complete DNA sequences of the mitochondrial genomes of the pathogenic yeasts Candida orthopsilosis and Candida metapsilosis: insight into the evolution of linear DNA genomes from mitochondrial telomere mutants.Nucleic acids research · 2006Article
- Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates.Current genetics · 2005Review
- Unique mitochondrial genome structure in diplonemids, the sister group of kinetoplastids.Eukaryotic cell · 2005Article
- Kinetoplast DNA network: evolution of an improbable structure.Eukaryotic cell · 2002Review
- Evolution of RNA editing in trypanosome mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2000Review
- Mitochondrial minicircles in the free-living bodonid Bodo saltans contain two gRNA gene cassettes and are not found in large networks.RNA (New York, N.Y.) · 2000Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitochondrial DNA (mtDNA) of a primitive kinetoplastid flagellate Cryptobia helicis is composed of 4.2 kb minicircles and 43 kb maxicircles. 85% and 6% of the minicircles are in the form of supercoiled (SC) and relaxed (OC) monomers, respectively. The remaining minicircles (9%) constitute catenated oligomers composed of both the SC and OC molecules. Minicircles contain bent helix and sequences homologous to the minicircle conserved sequence blocks. Maxicircles encode typical mitochondrial genes and are not catenated. The mtDNA, which we describe with the term 'pankinetoplast DNA', is spread throughout the mitochondrial lumen, where it is associated with multiple electron-lucent loci. There are approximately 8400 minicircles per pankinetoplast-mitochondrion, with the pan-kDNA representing approximately 36% of the total cellular DNA. Based on the similarity of the C.helicis minicircles to plasmids, we present a theory on the formation of the kDNA network.
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