ArticleMolecular biology of the cell1998
Activation of the p42 mitogen-activated protein kinase pathway inhibits Cdc2 activation and entry into M-phase in cycling Xenopus egg extracts.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Article
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- Robust production of recombinant phosphoproteins using cell-free protein synthesis.Nature communications · 2015Article
- Regulation of ERK-MAPK signaling in human epidermis.BMC systems biology · 2015Article
- Changes in oscillatory dynamics in the cell cycle of early Xenopus laevis embryos.PLoS biology · 2014Article
- Oncogenic Ras suppresses Cdk1 in a complex manner during the incubation of activated Xenopus egg extracts.Archives of biochemistry and biophysics · 2013Article
- Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.The Journal of biological chemistry · 2012Article
- Inhibitor-2 induced M-phase arrest in Xenopus cycling egg extracts is dependent on MAPK activation.Cellular & molecular biology letters · 2011Article
- Mitogen-activated protein/extracellular signal-regulated kinase kinase 1act/tubulin interaction is an important determinant of mitotic stability in cultured HT1080 human fibrosarcoma cells.Cancer research · 2010Article
- The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest.Molecular biology of the cell · 2009Article
- Mitogen-activated protein kinase kinase 1-dependent Golgi unlinking occurs in G2 phase and promotes the G2/M cell cycle transition.Molecular biology of the cell · 2007Article
- Mechanistic studies of the mitotic activation of Mos.Molecular and cellular biology · 2006Article
- Aurora A, mitotic entry, and spindle bipolarity.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Changes in regulatory phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during normal cell cycle progression and checkpoint arrests.Molecular biology of the cell · 2005Article
- Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis.Molecular and cellular biology · 2002Article
- Mitogen-activated protein kinase activation by oxidative and bacterial stress in an amphibian cell culture model.Environmental health perspectives · 2002Article
- Modulation of docetaxel-induced apoptosis and cell cycle arrest by all- trans retinoic acid in prostate cancer cells.British journal of cancer · 2001Article
- Mos activates MAP kinase in mouse oocytes through two opposite pathways.The EMBO journal · 2000Article
- The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway.Oncogene · 2000Article
- MEK and Cdc2 kinase are sequentially required for Golgi disassembly in MDCK cells by the mitotic Xenopus extracts.The Journal of cell biology · 2000Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have added constitutively active MAP kinase/ERK kinase (MEK), an activator of the mitogen-activated protein kinase (MAPK) signaling pathway, to cycling Xenopus egg extracts at various times during the cell cycle. p42MAPK activation during entry into M-phase arrested the cell cycle in metaphase, as has been shown previously. Unexpectedly, p42MAPK activation during interphase inhibited entry into M-phase. In these interphase-arrested extracts, H1 kinase activity remained low, Cdc2 was tyrosine phosphorylated, and nuclei continued to enlarge. The interphase arrest was overcome by recombinant cyclin B. In other experiments, p42MAPK activation by MEK or by Mos inhibited Cdc2 activation by cyclin B. PD098059, a specific inhibitor of MEK, blocked the effects of MEK(QP) and Mos. Mos-induced activation of p42MAPK did not inhibit DNA replication. These results indicate that, in addition to the established role of p42MAPK activation in M-phase arrest, the inappropriate activation of p42MAPK during interphase prevents normal entry into M-phase.
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