ArticleMolecular biology of the cell1998
A specific light chain of kinesin associates with mitochondria in cultured cells.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 105 citations in OpenAlex.
- Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity.Cell reports · 2022Article
- Molecular mechanism for kinesin-1 direct membrane recognition.Science advances · 2021Article
- Metaxins are core components of mitochondrial transport adaptor complexes.Nature communications · 2021Article
- Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.Molecular neurobiology · 2018Review
- Binucleate germ cells in Caenorhabditis elegans are removed by physiological apoptosis.PLoS genetics · 2018Article
- KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons.Traffic (Copenhagen, Denmark) · 2016Article
- Transendothelial migration: unifying principles from the endothelial perspective.Immunological reviews · 2016Review
- A Unique Role for Endothelial Cell Kinesin Light Chain 1, Variant 1 in Leukocyte Transendothelial Migration.The American journal of pathology · 2016Article
- Mechanisms of Polarized Organelle Distribution in Neurons.Frontiers in cellular neuroscience · 2016Review
- Ginsenoside Re rescues methamphetamine-induced oxidative damage, mitochondrial dysfunction, microglial activation, and dopaminergic degeneration by inhibiting the protein kinase Cδ gene.Molecular neurobiology · 2014Article
- Mitochondrial trafficking in neurons.Cold Spring Harbor perspectives in biology · 2013Review
- Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.Open biology · 2013Article
- Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila.Molecular biology of the cell · 2012Article
- The axonal transport of mitochondria.Journal of cell science · 2012Review
- Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells.Experimental brain research · 2012Review
- mmb1p binds mitochondria to dynamic microtubules.Current biology : CB · 2011Article
- Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility.The EMBO journal · 2011Article
- Evolutionary analysis of the kinesin light chain genes in the yellow fever mosquito Aedes aegypti: gene duplication as a source for novel early zygotic genes.BMC evolutionary biology · 2010Article
- Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Conventional kinesin holoenzymes are composed of heavy and light chain homodimers.Biochemistry · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The motor protein kinesin is implicated in the intracellular transport of organelles along microtubules. Kinesin light chains (KLCs) have been suggested to mediate the selective binding of kinesin to its cargo. To test this hypothesis, we isolated KLC cDNA clones from a CHO-K1 expression library. Using sequence analysis, they were found to encode five distinct isoforms of KLCs. The primary region of variability lies at the carboxyl termini, which were identical or highly homologous to carboxyl-terminal regions of rat KLC B and C, human KLCs, sea urchin KLC isoforms 1-3, and squid KLCs. To examine whether the KLC isoforms associate with different cytoplasmic organelles, we made an antibody specific for a 10-amino acid sequence unique to B and C isoforms. In an indirect immunofluorescence assay, this antibody specifically labeled mitochondria in cultured CV-1 cells and human skin fibroblasts. On Western blots of total cell homogenates, it recognized a single KLC isoform, which copurified with mitochondria. Taken together, these data indicate a specific association of a particular KLC (B type) with mitochondria, revealing that different KLC isoforms can target kinesin to different cargoes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.