ArticleThe Journal of general physiology1998
Adenosine triphosphate and the late steps in calcium-dependent exocytosis at a ribbon synapse.
Article in The Journal of general physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 83 citations in OpenAlex.
- Early Reduction in Mitochondrial Membrane Potential in Synaptic Mitochondria Contribute to Synaptic Pathology in the EAE Mouse Model of Multiple Sclerosis.International journal of molecular sciences · 2026Article
- Article
- Syntaxin 3B: A SNARE Protein Required for Vision.International journal of molecular sciences · 2024Review
- Presynaptic Proteins and Their Roles in Visual Processing by the Retina.Annual review of vision science · 2024Review
- Eliminating Synaptic Ribbons from Rods and Cones Halves the Releasable Vesicle Pool and Slows Down Replenishment.International journal of molecular sciences · 2022Article
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- Two Pools of Vesicles Associated with Synaptic Ribbons Are Molecularly Prepared for Release.Biophysical journal · 2017Article
- In Vivo Ribbon Mobility and Turnover of Ribeye at Zebrafish Hair Cell Synapses.Scientific reports · 2017Article
- A marginal band of microtubules transports and organizes mitochondria in retinal bipolar synaptic terminals.The Journal of general physiology · 2015Article
- Global Ca2+ signaling drives ribbon-independent synaptic transmission at rod bipolar cell synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Stabilization of spontaneous neurotransmitter release at ribbon synapses by ribbon-specific subtypes of complexin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Synaptic vesicle exocytosis in hippocampal synaptosomes correlates directly with total mitochondrial volume.Journal of molecular neuroscience : MN · 2013Article
- The dynamic architecture of photoreceptor ribbon synapses: cytoskeletal, extracellular matrix, and intramembrane proteins.Visual neuroscience · 2011Review
- Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle priming.Nature neuroscience · 2011Article
- Synaptic release at mammalian bipolar cell terminals.Visual neuroscience · 2011Review
- Calcium efflux systems in stress signaling and adaptation in plants.Frontiers in plant science · 2011Article
- Syntaxin 3B is essential for the exocytosis of synaptic vesicles in ribbon synapses of the retina.Neuroscience · 2010Article
- Evidence that exocytosis is driven by calcium entry through multiple calcium channels in goldfish retinal bipolar cells.Journal of neurophysiology · 2009Article
- The molecular architecture of ribbon presynaptic terminals.Molecular neurobiology · 2009Review
- Role of the synaptic ribbon in transmitting the cone light response.Nature neuroscience · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ATP dependence of the kinetics of Ca2+-dependent exocytosis after flash photolysis of caged Ca2+ was studied by capacitance measurements with submillisecond resolution in single synaptic terminals of retinal bipolar neurons. After control experiments verified that this combination of techniques is valid for the study of exocytosis in synaptic terminals, a comparison was made between the Ca2+ dependence of the rate of exocytosis in synaptic terminals internally dialyzed with MgATP, MgATP-gamma-S, or no added Mg2+ or nucleotide. The Ca2+ threshold for release, the maximum rate of release, and the overall relationship between the rate of synaptic vesicle fusion and [Ca2+]i were found to be independent of MgATP. A decrease in the average rate at near-threshold [Ca2+]i was observed in terminals with MgATP-gamma-S, but due to the small sample size is of unclear significance. The Ca2+ dependence of the delay between the elevation of [Ca2+]i and the beginning of the capacitance rise was also found to be independent of MgATP. In contrast, MgATP had a marked effect on the ability of terminals to respond to multiple stimuli. Terminals with MgATP typically exhibited a capacitance increase to a second stimulus that was >70% of the amplitude of the first response and to a third stimulus with a response amplitude that was >50% of the first, whereas terminals without MgATP responded to a second stimulus with a response <35% of the first and rarely responded to a third flash. These results suggest a major role for MgATP in preparing synaptic vesicles for fusion, but indicate that cytosolic MgATP may have little role in events downstream of calcium entry, provided that [Ca2+]i near release sites is elevated above approximately 30 microM.
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