ArticleThe Journal of general physiology1998
Modulation of the frequency of spontaneous sarcoplasmic reticulum Ca2+ release events (Ca2+ sparks) by myoplasmic [Mg2+] in frog skeletal muscle.
Article in The Journal of general physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Calcium-induced release of calcium in muscle: 50 years of work and the emerging consensus.The Journal of general physiology · 2018Review
- Synthetic localized calcium transients directly probe signalling mechanisms in skeletal muscle.The Journal of physiology · 2012Article
- Modulation of the local SR Ca2+ release by intracellular Mg2+ in cardiac myocytes.The Journal of general physiology · 2008Article
- Effect of mitochondria poisoning by FCCP on Ca2+ signaling in mouse skeletal muscle fibers.Pflugers Archiv : European journal of physiology · 2008Article
- Mini-dystrophin expression down-regulates IP3-mediated calcium release events in resting dystrophin-deficient muscle cells.The Journal of general physiology · 2006Article
- Automated detection of elementary calcium release events using the á trous wavelet transform.Biophysical journal · 2006Article
- Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling?The Journal of general physiology · 2004Article
- Effects of ryanoids on spontaneous and depolarization-evoked calcium release events in frog muscle.Biophysical journal · 2004Article
- Calmodulin modulates initiation but not termination of spontaneous Ca2+ sparks in frog skeletal muscle.Biophysical journal · 2003Article
- Simulation of calcium sparks in cut skeletal muscle fibers of the frog.The Journal of general physiology · 2003Article
- PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure.The Journal of cell biology · 2003Article
- Interdomain interactions within ryanodine receptors regulate Ca2+ spark frequency in skeletal muscle.The Journal of general physiology · 2002Article
- Calcium sparks in intact skeletal muscle fibers of the frog.The Journal of general physiology · 2001Article
- Spark- and ember-like elementary Ca2+ release events in skinned fibres of adult mammalian skeletal muscle.The Journal of physiology · 2001Article
- Calcium release in skeletal muscle: from K+ contractures to Ca2+ sparks.Journal of muscle research and cell motility · 2001Review
- Fast imaging in two dimensions resolves extensive sources of Ca2+ sparks in frog skeletal muscle.The Journal of physiology · 2000Article
- Effects of imperatoxin A on local sarcoplasmic reticulum Ca(2+) release in frog skeletal muscle.Biophysical journal · 2000Article
- Two mechanisms for termination of individual Ca2+ sparks in skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Expression of ryanodine receptor RyR3 produces Ca2+ sparks in dyspedic myotubes.The Journal of physiology · 2000Article
- Involvement of multiple intracellular release channels in calcium sparks of skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The modulation by internal free [Mg2+] of spontaneous calcium release events (Ca2+ "sparks") from the sarcoplasmic reticulum (SR) was studied in depolarized notched frog skeletal muscle fibers using a laser scanning confocal microscope in line-scan mode (x vs. t). Over the range of [Mg2+] from 0.13 to 1.86 mM, decreasing the [Mg2+] induced an increase in the frequency of calcium release events in proportion to [Mg2+]-1.6. The change of event frequency was not due to changes in [Mg-ATP] or [ATP]. Analysis of individual SR calcium release event properties showed that the variation in event frequency induced by the change of [Mg2+] was not accompanied by any changes in the spatiotemporal spread (i.e., spatial half width or temporal half duration) of Ca2+ sparks. The increase in event frequency also had no effect on the distribution of event amplitudes. Finally, the rise time of calcium sparks was independent of the [Mg2+], indicating that the open time of the SR channel or channels underlying spontaneous calcium release events was not altered by [Mg2+] over the range tested. These results suggest that in resting skeletal fibers, [Mg2+] modulates the SR calcium release channel opening frequency by modifying the average closed time of the channel without altering the open time. A kinetic reaction scheme consistent with our results and those of bilayer and SR vesicle experiments indicates that physiological levels of resting Mg2+ may inhibit channel opening by occupying the site for calcium activation of the SR calcium release channel.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.