ArticleThe Journal of experimental medicine1998
Disruption of fas receptor signaling by nitric oxide in eosinophils.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 176 citations in OpenAlex.
- CS-NO releasing hydrogel protects against neuron apoptosis and inflammation through suppressing the HIF-1α and MAPK pathway in stroke.Materials today. Bio · 2026Article
- Analysis of the Serum Profile of Cytokines Involved in the T-Helper Cell Type 17 Immune Response Pathway in Atopic Children with Food Allergy.International journal of environmental research and public health · 2022Article
- The potential of proliferative and apoptotic parameters in clinical flow cytometry of myeloid malignancies.Blood advances · 2021Review
- Potent Anti-Inflammatory Effects of Tetracyclines on Human Eosinophils.Frontiers in allergy · 2021Article
- Apoptosis of Eosinophil Granulocytes.Biology · 2020Review
- β-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression.Cell death & disease · 2020Article
- IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide.Stem cell research & therapy · 2019Article
- Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis.The Korean journal of parasitology · 2017Review
- Mitochondria in the center of human eosinophil apoptosis and survival.International journal of molecular sciences · 2014Review
- Nitric oxide-induced apoptosis of human dental pulp cells is mediated by the mitochondria-dependent pathway.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2014Article
- Regulation of spontaneous eosinophil apoptosis-a neglected area of importance.Journal of cell death · 2014Review
- Essential roles of PKA, iNOS, CD95/CD95L, and terminal caspases in suppression of eosinopoiesis by PGE2 and other cAMP-elevating agents.TheScientificWorldJournal · 2013Article
- Human eosinophils release IL-1ß and increase expression of IL-17A in activated CD4+ T lymphocytes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Article
- Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation.Respiratory research · 2012Article
- Curcumin suppresses ovalbumin-induced allergic conjunctivitis.Molecular vision · 2012Article
- Increase of nitrosative stress in patients with eosinophilic pneumonia.Respiratory research · 2011Article
- Eosinophil survival and apoptosis in health and disease.Allergy, asthma & immunology research · 2010Article
- Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils.The Journal of experimental medicine · 2004Article
- Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Distinct effects of ceramide-generating pathways in prostate adenocarcinoma cells.British journal of pharmacology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that Fas ligand-Fas receptor interactions are involved in the regulation of eosinophil apoptosis and that dysfunctions in this system could contribute to the accumulation of these cells in allergic and asthmatic diseases. Here, we demonstrate that nitric oxide (NO) specifically prevents Fas receptor-mediated apoptosis in freshly isolated human eosinophils. In contrast, rapid acceleration of eosinophil apoptosis by activation of the Fas receptor occurs in the presence of eosinophil hematopoietins. Analysis of the intracellular mechanisms revealed that NO disrupts Fas receptor-mediated signaling events at the level of, or proximal to, Jun kinase (JNK), but distal to sphingomyelinase (SMase) activation and ceramide generation. In addition, activation of SMase occurs downstream of an interleukin 1 converting enzyme-like (ICE-like) protease(s) that is not blocked by NO. However, NO prevents activation of a protease that targets lamin B1. These findings suggest a role for an additional NO-sensitive apoptotic signaling pathway that amplifies the proteolytic cascade initialized by activation of the Fas receptor. Therefore, NO concentrations within allergic inflammatory sites may be important in determining whether an eosinophil survives or undergoes apoptosis upon Fas ligand stimulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.