ArticleThe Journal of clinical investigation1998
Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 266 citations in OpenAlex.
- Article
- Hepatic Macrophage Abundance and Phenotype in Aging and Liver Iron Accumulation.International journal of molecular sciences · 2022Article
- Identification and local manipulation of bone marrow vasculature during intravital imaging.Scientific reports · 2020Article
- Aging results in accumulation of M1 and M2 hepatic macrophages and a differential response to gadolinium chloride.Histochemistry and cell biology · 2020Article
- Inhibition of Heme Oxygenase Antioxidant Activity Exacerbates Hepatic Steatosis and FibrosisAntioxidants (Basel, Switzerland) · 2019Article
- Hepatocellular heme oxygenase 1 deficiency does not affect inflammatory hepcidin regulation in mice.PloS one · 2019Article
- Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1.Journal of clinical biochemistry and nutrition · 2018Review
- Quantitative imaging mass spectroscopy reveals roles of heme oxygenase-2 for protecting against transhemispheric diaschisis in the brain ischemia.Journal of clinical biochemistry and nutrition · 2018Article
- Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.Nature communications · 2018Article
- The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis.Hepatology (Baltimore, Md.) · 2018Article
- Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress.International journal of hepatology · 2018Article
- Ischemia/Reperfusion.Comprehensive Physiology · 2016Review
- Heme Oxygenases in Cardiovascular Health and Disease.Physiological reviews · 2016Review
- Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury.World journal of gastroenterology · 2016Article
- HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.Nature communications · 2016Article
- Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.Nature communications · 2016Article
- Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis.Journal of cellular and molecular medicine · 2015Article
- Protective role of hemeoxygenase-1 in gastrointestinal diseases.Cellular and molecular life sciences : CMLS · 2015Review
- Biological evaluation of liposome-encapsulated hemoglobin surface-modified with a novel PEGylated nonphospholipid amphiphile.Artificial organs · 2014Article
- Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver.Microcirculation (New York, N.Y. : 1994) · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbon monoxide (CO) derived from heme oxygenase has recently been shown to play a role in controlling hepatobiliary function, but intrahepatic distribution of the enzyme is unknown. We examined distribution of two kinds of the heme oxygenase isoforms (HO-1 and HO-2) in rat liver immunohistochemically using monoclonal antibodies. The results showed that distribution of the two isoforms had distinct topographic patterns: HO-1, an inducible isoform, was observed only in Kupffer cells, while HO-2, a constitutive form, distributed to parenchymal cells, but not to Kupffer cells. Both isoforms were undetectable in hepatic stellate cells and sinusoidal endothelial cells. Of the two isoforms, HO-2 in the parenchymal cell rather than HO-1 in the Kupffer cell, appears to play a major role in regulation of microvascular tone. In the perfused liver, administration of HbO2, a CO-trapping reagent that can diffuse across the fenestrated endothelium into the space of Disse, elicited a marked sinusoidal constriction, while administration of a liposome-encapsulated Hb that cannot enter the space had no effect on the microvascular tone. These results suggest that CO evolved by HO-2 in the parenchymal cells, and, released to the extrasinusoidal space, served as the physiological relaxant for hepatic sinusoids.
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