ArticleBiophysical journal1998
Origins of individual swimming behavior in bacteria.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Identification of the governing equation of stimulus-response data for run-and-tumble dynamics.PLoS computational biology · 2025Article
- Temporal fluctuations in chemotaxis gain implement a simulated-tempering strategy for efficient navigation in complex environments.iScience · 2021Article
- Effect of inoculum size and antibiotics on bacterial traveling bands in a thin microchannel defined by optical adhesive.Microsystems & nanoengineering · 2021Article
- Cellular Stoichiometry of Chemotaxis Proteins inJournal of bacteriology · 2020Article
- Evidence of Robustness in a Two-Component System Using a Synthetic Circuit.Journal of bacteriology · 2020Article
- Bacterial chemotaxis in a microfluidic T-maze reveals strong phenotypic heterogeneity in chemotactic sensitivity.Nature communications · 2019Article
- Behavioral Variability and Phenotypic Diversity in Bacterial Chemotaxis.Annual review of biophysics · 2018Review
- Mathematical Analysis of the Escherichia coli Chemotaxis Signalling Pathway.Bulletin of mathematical biology · 2018Article
- Cellular Stoichiometry of Methyl-Accepting Chemotaxis Proteins in Sinorhizobium meliloti.Journal of bacteriology · 2018Article
- Non-genetic diversity modulates population performance.Molecular systems biology · 2016Article
- Direct Correlation between Motile Behavior and Protein Abundance in Single Cells.PLoS computational biology · 2016Article
- Enhancement of Swimming Speed Leads to a More-Efficient Chemotactic Response to Repellent.Applied and environmental microbiology · 2016Article
- Response thresholds in bacterial chemotaxis.Science advances · 2015Article
- Fundamental constraints on the abundances of chemotaxis proteins.Biophysical journal · 2015Article
- Understanding the link between single cell and population scale responses of Escherichia coli in differing ligand gradients.Computational and structural biotechnology journal · 2015Article
- A scalable computational framework for establishing long-term behavior of stochastic reaction networks.PLoS computational biology · 2014Article
- Excitation and adaptation in bacteria-a model signal transduction system that controls taxis and spatial pattern formation.International journal of molecular sciences · 2013Article
- Article
- On-chip cellomics assay enabling algebraic and geometric understanding of epigenetic information in cellular networks of living systems. 1. Temporal aspects of epigenetic information in bacteria.Sensors (Basel, Switzerland) · 2012Review
- Multi-scale modeling in biology: how to bridge the gaps between scales?Progress in biophysics and molecular biology · 2011Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Cells in a cloned population of coliform bacteria exhibit a wide range of swimming behaviors--a form of non-genetic individuality. We used computer models to examine the proposition that these variations are due to differences in the number of chemotaxis signaling molecules from one cell to the next. Simulations were run in which the concentrations of seven gene products in the chemotaxis pathway were changed either deterministically or stochastically, with the changes derived from independent normal distributions. Computer models with two adaptation mechanisms were compared with experimental results from observations on individuals drawn from genetically identical populations. The range of swimming behavior predicted for cells with a standard deviation of protein copy number per cell of 10% of the mean was found to match closely the experimental range of the wild-type population. We also make predictions for the swimming behaviors of mutant strains lacking the adaptational mechanism that can be tested experimentally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.