ArticleBiophysical journal1998
Oscillatory pericellular proteolysis and oxidant deposition during neutrophil locomotion.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed.
- Migratory responses in enucleated cells: The forces driving the locomotion movement of unicellular organisms.PNAS nexus · 2025Article
- Self-Organization and Information Processing: From Basic Enzymatic Activities to Complex Adaptive Cellular Behavior.Frontiers in genetics · 2021Review
- Therapeutic targeting of neutrophil exocytosis.Journal of leukocyte biology · 2020Review
- Time and Demand are Two Critical Dimensions of Immunometabolism: The Process of Macrophage Activation and the Pentose Phosphate Pathway.Frontiers in immunology · 2015Review
- Elements of the cellular metabolic structure.Frontiers in molecular biosciences · 2015Article
- αCellular and molecular bioengineering · 2014Article
- Article
- The metabolic core and catalytic switches are fundamental elements in the self-regulation of the systemic metabolic structure of cells.PloS one · 2011Article
- Quantitative analysis of cellular metabolic dissipative, self-organized structures.International journal of molecular sciences · 2010Review
- Global self-regulation of the cellular metabolic structure.PloS one · 2010Article
- Article
- Article
- Elevated glucose concentrations promote receptor-independent activation of adherent human neutrophils: an experimental and computational approach.Biophysical journal · 2007Article
- Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments.The Journal of general physiology · 2004Article
- Pericellular proteolysis by leukocytes and tumor cells on substrates: focal activation and the role of urokinase-type plasminogen activator.Histochemistry and cell biology · 2004Article
- A model of the oscillatory metabolism of activated neutrophils.Biophysical journal · 2003Article
- Pregnancy alters glucose-6-phosphate dehydrogenase trafficking, cell metabolism, and oxidant release of maternal neutrophils.The Journal of clinical investigation · 2002Article
- Phorbol ester induces elevated oxidative activity and alkalization in a subset of lysosomes.BMC cell biology · 2002Article
- Apparent role of traveling metabolic waves in oxidant release by living neutrophils.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Interactions of integrins with their partner proteins in leukocyte membranes.Immunologic research · 2002Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
To better understand the mechanism of leukocyte migration in complex environments, model extracellular matrices were prepared using gelatin, Hanks' solution, Bodipy-BSA (fluorescent upon proteolysis), and dihydrotetramethylrosamine or hydroethidine (fluorescent upon oxidation). Using quantitative microfluorometry, neutrophil-mediated extracellular pulses of reactive oxygen metabolites (ROMs) and pericellular proteolysis were periodically observed showing that these functions occur as quantal bursts. However, chronic granulomatous disease neutrophils, which do not produce ROMs, did not display ROM deposition. Matrices show an alternating pattern of green (proteolytic) and red (oxidative) fluorescence, indicating these functions are out of phase. Electric fields phase-matched with metabolic oscillations, which increase the amplitude of intracellular NAD(P)H oscillations, increase ROM deposition and pericellular proteolysis; this further supports the link between intracellular chemical oscillators and extracellular functions. This phase relationship may allow ROMs to inactivate protease inhibitors, followed by protease activation.
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Registered trials
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