ArticleProceedings of the National Academy of Sciences of the United States of America1998
Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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Who cites it
59 citing papers in PubMed, 144 citations in OpenAlex.
- CCAN forms the spherical shell-like structure in interphase kinetochores.Science advances · 2026Article
- Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation.Developmental cell · 2026Article
- CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation.Life science alliance · 2025Article
- Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells.The Journal of cell biology · 2024Article
- The rate of de novo structural variation is increased in in vitro-produced offspring and preferentially affects the paternal genome.Genome research · 2023Article
- High-resolution structural variants catalogue in a large-scale whole genome sequenced bovine family cohort data.BMC genomics · 2023Article
- Kinetochore Architecture Employs Diverse Linker Strategies Across Evolution.Frontiers in cell and developmental biology · 2022Review
- Immunization with CENP-C Causes Aberrant Chromosome Segregation during Oocyte Meiosis in Mice.Journal of immunology research · 2021Article
- A fraction of barrier-to-autointegration factor (BAF) associates with centromeres and controls mitosis progression.Communications biology · 2020Article
- CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model.Cancer science · 2020Article
- Maternal factors regulating preimplantation development in mice.Current topics in developmental biology · 2020Review
- Cellular and Molecular Mechanisms of Centromere Drive.Cold Spring Harbor symposia on quantitative biology · 2017Article
- Kinetochore assembly and function through the cell cycle.Chromosoma · 2016Review
- Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential.Nature communications · 2016Article
- Nuclear accumulation of annexin A2 contributes to chromosomal instability by coilin-mediated centromere damage.Oncogene · 2015Article
- The dimerization domain of PfCENP-C is required for its functions as a centromere protein in human malaria parasite Plasmodium falciparum.Malaria journal · 2014Article
- Comparative study of artificial chromosome centromeres in human and murine cells.European journal of human genetics : EJHG · 2013Article
- The ABCs of CENPs.Chromosoma · 2011Review
- Cug2 is essential for normal mitotic control and CNS development in zebrafish.BMC developmental biology · 2011Article
- Epigenetic mechanisms and genome stability.Clinical epigenetics · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Centromere protein C (CENPC) is a key protein that has been localized to the inner kinetochore plate of active mammalian centromeres. Using gene targeting techniques, we have disrupted the mouse Cenpc gene and shown that the gene is essential for normal mouse embryonic development. Heterozygous mice carrying one functional copy of the gene are healthy and fertile, whereas homozygous embryos fail to thrive. In these embryos, mitotic arrest and gross morphological degeneration become apparent as early as the morula stage of development. The degenerating embryos demonstrate highly irregular cell and nuclear morphologies, including the presence of a large number of micronuclei. Mitotic chromosomes of these embryos display a scattered and often highly condensed configuration and do not segregate in an ordered fashion. These results describing the phenotype of the mutant mouse embryos indicate that CENPC has a direct role in the mitotic progression from metaphase to anaphase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.