ArticleProceedings of the National Academy of Sciences of the United States of America1998
The rat gene homologous to the human gene 9-27 is involved in the development of the mammary gland.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 24 citations in OpenAlex.
- Characterization of the osteoblast-specific transmembrane protein IFITM5 and analysis of IFITM5-deficient mice.Journal of bone and mineral metabolism · 2011Article
- Distinct populations of tumor-initiating cells derived from a tumor generated by rat mammary cancer stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The properties of a mammary gland cancer stem cell.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes.Genes and immunity · 2006Article
- Association of rat8 with Fyn protein kinase via lipid rafts is required for rat mammary cell differentiation in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Proteomic dissection of dome formation in a mammary cell line.Journal of mammary gland biology and neoplasia · 2002Review
- Dome formation in cell cultures as expression of an early stage of lactogenic differentiation of the mammary gland.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Changes of the ganglioside pattern and content in human fibroblasts by high density cell population subculture progression.Glycoconjugate journal · 2002Article
- Proteomic dissection of dome formation in a mammary cell line: role of tropomyosin-5b and maspin.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Genetic dissection of dome formation in a mammary cell line: identification of two genes with opposing action.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have developed a model system for studying differentiation in the mammary gland, by using two clonal cultures deriving from a rat breast adenocarcinoma. They differ in the ability to form domes, structures the significance of which is unknown. By using the subtractive cDNA library approach, we isolated a cDNA that is highly expressed in the dome-forming cells, and identical to the rat8 gene and highly homologous to the human 9-27 gene. Antisense treatment of the dome-forming cells specifically and reproducibly abolishes dome formation, while forced expression of the gene in non-dome-forming cells causes morphological changes suggestive of "flat" domes. In situ hybridization on rat tissues shows that the gene is expressed in epithelia, especially in those forming tubular structures, suggesting a relatedness between these structures and domes. Cytokeratin 8 and E cadherin are strongly expressed in the domes but not outside them, suggesting that the rat8 gene triggers the cells to express molecules that tighten the lateral connections between the cells; the process is likely to parallel that occurring during the differentiation of the mammary gland.
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