ArticleProceedings of the National Academy of Sciences of the United States of America1998
Opening-up of liposomal membranes by talin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 137 citations in OpenAlex.
- Topology and kinetic pathways of colloidosome assembly and disassembly.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Environmental Toxicants and Their Disruption of Integrin Signaling in Lipid Rafts.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- The Art of Viral Membrane Fusion and Penetration.Sub-cellular biochemistry · 2023Article
- To Close or to Collapse: The Role of Charges on Membrane Stability upon Pore Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Toward a unified picture of the exocytotic fusion pore.FEBS letters · 2018Review
- Formation and size distribution of self-assembled vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2017Review
- Free energy of the edge of an open lipid bilayer based on the interactions of its constituent molecules.International journal of non-linear mechanics · 2015Article
- Model systems for studying cell adhesion and biomimetic actin networks.Beilstein journal of nanotechnology · 2014Review
- Multiple membrane interactions and versatile vesicle deformations elicited by melittin.Toxins · 2013Article
- Equilibrium theory and geometrical constraint equation for two-component lipid bilayer vesicles.Journal of biological physics · 2008Article
- Modelling and simulations of multi-component lipid membranes and open membranes via diffuse interface approaches.Journal of mathematical biology · 2008Article
- Single GUV method reveals interaction of tea catechin (-)-epigallocatechin gallate with lipid membranes.Biophysical journal · 2007Article
- General mathematical frame for open or closed biomembranes (Part I): equilibrium theory and geometrically constraint equation.Journal of mathematical biology · 2005Article
- Equilibrium shape equation and geometrically permissible condition for two-component lipid bilayer vesicles.Journal of biological physics · 2005Article
- Electro-deformation and poration of giant vesicles viewed with high temporal resolution.Biophysical journal · 2005Article
- Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.The EMBO journal · 2004Article
- Microscopic observations reveal that fusogenic peptides induce liposome shrinkage prior to membrane fusion.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Kinetics of the micelle-to-vesicle transition: aqueous lecithin-bile salt mixtures.Biophysical journal · 2003Article
- Cascades of transient pores in giant vesicles: line tension and transport.Biophysical journal · 2003Article
- Morphological and topological transformation of membrane vesicles.Journal of biological physics · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphological changes of liposomes caused by interactions between liposomal membranes and talin, a cytoskeletal submembranous protein, were studied by direct, real-time observation by using high-intensity dark-field microscopy. Surprisingly, when talin was added to a liposome solution, liposomes opened stable holes and were transformed into cup-shaped liposomes. The holes became larger with increasing talin concentration, and finally the cup-shaped liposomes were transformed into lipid bilayer sheets. These morphological changes were reversed by protein dilution, i.e., the sheets could be transformed back into closed spherical liposomes. We demonstrated that talin was localized mainly along the membrane verges, presumably avoiding exposure of its hydrophobic portion at the edge of the lipid bilayer. This is the first demonstration that a lipid bilayer can stably maintain a free verge in aqueous solution. This finding refutes the established dogma that all lipid bilayer membranes inevitably form closed vesicles and suggests that talin is a useful tool for manipulating liposomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.