ArticleProceedings of the National Academy of Sciences of the United States of America1998
ATP-enhanced molecular chaperone functions of the small heat shock protein human alphaB crystallin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 142 citations in OpenAlex.
- NMR-guided rational exploration of co-factors in boosting theMagnetic resonance letters · 2025Article
- Effect of epigallocatechin gallate in green tea on preventing lens opacity and αB-crystallin aggregation in rat model of diabetes.International journal of ophthalmology · 2023Article
- Role of ATP-Small Heat Shock Protein Interaction in Human Diseases.Frontiers in molecular biosciences · 2022Review
- Inorganic Polyphosphates As Storage for and Generator of Metabolic Energy in the Extracellular Matrix.Chemical reviews · 2019Review
- Improving stress tolerance and cell integrity of Rhodococcus ruber by overexpressing small-shock-protein Hsp16 of Rhodococcus.Journal of industrial microbiology & biotechnology · 2018Article
- Oligomeric structure and chaperone-like activity of Drosophila melanogaster mitochondrial small heat shock protein Hsp22 and arginine mutants in the alpha-crystallin domain.Cell stress & chaperones · 2017Article
- Alpha-crystallin-derived peptides as therapeutic chaperones.Biochimica et biophysica acta · 2016Review
- Interaction of ATP with a small heat shock protein from Mycobacterium leprae: effect on its structure and function.PLoS neglected tropical diseases · 2015Article
- In vivo substrate diversity and preference of small heat shock protein IbpB as revealed by using a genetically incorporated photo-cross-linker.The Journal of biological chemistry · 2013Article
- Novel roles for α-crystallins in retinal function and disease.Progress in retinal and eye research · 2012Review
- Myofibrillar myopathies.Neuromuscular disorders : NMD · 2011Review
- Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase.Biochemical and biophysical research communications · 2010Article
- The endoplasmic reticulum chaperone Cosmc directly promotes in vitro folding of T-synthase.The Journal of biological chemistry · 2010Article
- Lens aging: effects of crystallins.Biochimica et biophysica acta · 2009Review
- The box H/ACA snoRNP assembly factor Shq1p is a chaperone protein homologous to Hsp90 cochaperones that binds to the Cbf5p enzyme.Journal of molecular biology · 2009Article
- Chemical modulation of the chaperone function of human alphaA-crystallin.Journal of biochemistry · 2008Article
- Alpha-crystallin assisted refolding of enzyme substrates: optimization of external parameters.The protein journal · 2007Article
- Effect of site-directed mutagenesis of methylglyoxal-modifiable arginine residues on the structure and chaperone function of human alphaA-crystallin.Biochemistry · 2006Article
- The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress.Journal of molecular neuroscience : MN · 2006Article
- Alphab-crystallin-assisted reactivation of glucose-6-phosphate dehydrogenase upon refolding.The Biochemical journal · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We report direct experimental evidence that human alphaB-crystallin, a member of the small heat shock protein family, actively participates in the refolding of citrate synthase (CS) in vitro. In the presence of 3.5 mM ATP, CS reactivation by alphaB-crystallin was enhanced approximately twofold. Similarly, 3.5 mM ATP enhanced the chaperone activity of alphaB-crystallin on the unfolding and aggregation of CS at 45 degrees C. Consistent with these findings, cell viability at 50 degrees C was improved nearly five orders of magnitude in Escherichia coli expressing alphaB-crystallin. SDS/PAGE analysis of cell lysates suggested that alphaB-crystallin protects cells against physiological stress in vivo by maintaining cytosolic proteins in their native and functional conformations. This report confirms the action of alphaB-crystallin as a molecular chaperone both in vitro and in vivo and describes the enhancement of alphaB-crystallin chaperone functions by ATP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.