ArticleMolecular and cellular biology1998
Increase in p202 expression during skeletal muscle differentiation: inhibition of MyoD protein expression and activity by p202.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 92 citations in OpenAlex.
- Activation and Immune Regulation Mechanisms of PYHIN Family During Microbial Infection.Frontiers in microbiology · 2021Review
- The interferon-inducible protein p202 promotes osteogenesis in mouse bone marrow stromal cells.Bioscience reports · 2018Article
- The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Article
- Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Review
- Interferon-inducible Ifi200-family genes in systemic lupus erythematosus.Immunology letters · 2008Review
- Article
- Expression of IFI 16 in epithelial cells and lymphoid tissues.Histochemistry and cell biology · 2003Article
- The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins.Molecular and cellular biology · 2002Article
- p202, an interferon-inducible negative regulator of cell growth, is a target of the adenovirus E1A protein.Oncogene · 2001Article
- Antiviral actions of interferons.Clinical microbiology reviews · 2001Review
- Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16.Oncogene · 2000Article
- MyoD-dependent induction during myoblast differentiation of p204, a protein also inducible by interferon.Molecular and cellular biology · 2000Article
- The retinoblastoma protein is an essential mediator that links the interferon-inducible 204 gene to cell-cycle regulation.Oncogene · 2000Article
- The 2'-5' oligoadenylate/RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation.Molecular and cellular biology · 2000Article
- Transcription and growth regulatory functions of the HIN-200 family of proteins.Molecular and cellular biology · 1999Review
- The interferon-inducible nucleolar p204 protein binds the ribosomal RNA-specific UBF1 transcription factor and inhibits ribosomal RNA transcription.The EMBO journal · 1999Article
- Reduced growth rate and transformation phenotype of the prostate cancer cells by an interferon-inducible protein, p202.Oncogene · 1999Article
- Regulation of differentiation by HBP1, a target of the retinoblastoma protein.Molecular and cellular biology · 1998Article
- p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiation.Cytokine & growth factor reviewsReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
p202 is a primarily nuclear, interferon-inducible murine protein that is encoded by the Ifi 202 gene. Overexpression of p202 in transfected cells retards cell proliferation. p202 modulates the pattern of gene expression by inhibiting the activity of various transcription factors including NF-kappaB, c-Fos, c-Jun, E2F-1, and p53. Here we report that p202 was constitutively expressed in mouse skeletal muscle and that the levels of 202 RNA and p202 greatly increased during the differentiation of cultured C2C12 myoblasts to myotubes. When overexpressed in transfected myoblasts, p202 inhibited the expression of one muscle protein (MyoD) without affecting the expression of a second one (myogenin). Thus, the decrease in the level of MyoD (but not of myogenin) during muscle differentiation may be the consequence of the increase in p202 level. Overexpressed p202 also inhibited the transcriptional activity of both MyoD and myogenin. This inhibition was correlated with an interaction of p202 with both proteins, as well as the inhibition by p202 of the sequence-specific binding of both proteins to DNA. This inhibition of the expression of MyoD and of the transcriptional activity of MyoD and myogenin may account for the inhibition of the induction of myoblast differentiation by premature overexpression of p202.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.