ArticleMolecular and cellular biology1998
POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 145 citations in OpenAlex.
- Linking metabolic dysfunction with cardiovascular diseases: Brn-3b/POU4F2 transcription factor in cardiometabolic tissues in health and disease.Cell death & disease · 2021Review
- Transcriptional regulation of prolactin in a euryhaline teleost: Characterisation of gene promoters through in silico and transcriptome analyses.Journal of neuroendocrinology · 2020Review
- Transcription factors Brn-3α and TRIM16 in cancers, association with hormone reception.Heliyon · 2019Review
- ERα is required for suppressing OCT4-induced proliferation of breast cancer cells via DNMT1/ISL1/ERK axis.Cell proliferation · 2019Article
- Hsp-27 induction requires POU4F2/Brn-3b TF in doxorubicin-treated breast cancer cells, whereas phosphorylation alters its cellular localisation following drug treatment.Cell stress & chaperones · 2011Article
- Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway.Breast cancer research : BCR · 2011Article
- A simple technique for the prediction of interacting proteins reveals a direct Brn-3a-androgen receptor interaction.The Journal of biological chemistry · 2010Article
- Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes.Endocrinology · 2009Article
- Estrogen is not neuroprotective in a rodent model of optic nerve stroke.Molecular vision · 2007Article
- Brn-3a neuronal transcription factor functional expression in human prostate cancer.Prostate cancer and prostatic diseases · 2006Article
- Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.Nucleic acids research · 2006Article
- Article
- Role of homeobox genes in normal mammary gland development and breast tumorigenesis.Journal of mammary gland biology and neoplasia · 2003Review
- Estrogen and Bcl-2: gene induction and effect of transgene in experimental stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Article
- The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells.Oncogene · 1999Article
- Multifunctional role of the Pitx2 homeodomain protein C-terminal tail.Molecular and cellular biology · 1999Article
- Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding.Molecular and cellular biology · 1999Article
- Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization.Molecular and cellular biology · 1999Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The estrogen receptor (ER) modulates transcription by forming complexes with other proteins and then binding to the estrogen response element (ERE). We have identified a novel interaction of this receptor with the POU transcription factors Brn-3a and Brn-3b which was independent of ligand binding. By pull-down assays and the yeast two-hybrid system, the POU domain of Brn-3a and Brn-3b was shown to interact with the DNA-binding domain of the ER. Brn-3-ER interactions also affect transcriptional activity of an ERE-containing promoter, such that in estradiol-stimulated cells, Brn-3b strongly activated the promoter via the ERE, while Brn-3a had a mild inhibitory effect. The POU domain of Brn-3b which interacts with the ER was sufficient to confer this activation potential, and the change of a single amino acid in the first helix of the POU homeodomain of Brn-3a to its equivalent in Brn-3b can change the mild repressive effect of Brn-3a to a stimulatory Brn-3b-like effect. These observations and their implications for transcriptional regulation by the ER are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.