ArticleMolecular and cellular biology1998
Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 86 citations in OpenAlex.
- NAT10-mediated upregulation of GAS5 facilitates immune cell infiltration in non-small cell lung cancer via the MYBBP1A-p53/IRF1/type I interferon signaling axis.Cell death discovery · 2024Article
- BAZ1B the Protean Protein.Genes · 2021Review
- The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness.Cancers · 2020Review
- Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation inRNA (New York, N.Y.) · 2019Article
- c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer.Molecular oncology · 2019Article
- Article
- The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability.Molecular biotechnology · 2016Article
- Review
- Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.The Journal of biological chemistry · 2012Article
- Epigeneitc silencing of ribosomal RNA genes by Mybbp1a.Journal of biomedical science · 2012Article
- Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis.The EMBO journal · 2012Article
- Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells.BMC cancer · 2012Article
- Article
- The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer.Frontiers in oncology · 2012Article
- RNA content in the nucleolus alters p53 acetylation via MYBBP1A.The EMBO journal · 2011Article
- Quantitative proteomics identifies the Myb-binding protein p160 as a novel target of the von Hippel-Lindau tumor suppressor.PloS one · 2011Article
- MYBBP1A: a new Ipr1's binding protein in mice.Molecular biology reports · 2010Article
- Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase.The Journal of biological chemistry · 2010Article
- Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter.Nucleic acids research · 2009Article
- Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.Molecular and cellular biology · 2008Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously detected two related murine nuclear proteins, p160 and p67, that can bind to the leucine zipper motif within the negative regulatory domain of the Myb transcription factor. We now describe the molecular cloning of cDNA corresponding to murine p160. The P160 gene is located on mouse chromosome 11, and related sequences are found on chromosomes 1 and 12. The predicted p160 protein is novel, and in agreement with previous studies, we find that the corresponding 4.5-kb mRNA is ubiquitously expressed. We showed that p67 is an N-terminal fragment of p160 which is generated by proteolytic cleavage in certain cell types. The protein encoded by the cloned p160 cDNA and an engineered protein (p67*) comprising the amino-terminal region of p160 exhibit binding specificities for the Myb and Jun leucine zipper regions identical to those of endogenous p160 and p67, respectively. This implies that the Myb-binding site of p160 lies within the N-terminal 580 residues and that the Jun-binding site is C-terminal to this position. Moreover, we show that p67* but not p160 can inhibit transactivation by Myb. Unexpectedly, immunofluorescence studies show that p160 is localized predominantly in the nucleolus. The implications of these results for possible functions of p160 are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.