ArticleJournal of virology1998
Differential tropism and chemokine receptor expression of human immunodeficiency virus type 1 in neonatal monocytes, monocyte-derived macrophages, and placental macrophages.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 81 citations in OpenAlex.
- Monocytes and macrophages in COVID-19: Friends and foes.Life sciences · 2021Review
- Placental Macrophage (Hofbauer Cell) Responses to Infection During Pregnancy: A Systematic Scoping Review.Frontiers in immunology · 2021Article
- Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection.Current HIV research · 2014Review
- Relevance of early detection of HIV type 1 SI/CXCR4-using viruses in vertically infected children.AIDS research and human retroviruses · 2012Article
- Histomorphometric and immunohistochemical analysis of infectious agents, T-cell subpopulations and inflammatory adhesion molecules in placentas from HIV-seropositive pregnant women.Diagnostic pathology · 2011Article
- Different regions of HIV-1 subtype C env are associated with placental localization and in utero mother-to-child transmission.Journal of virology · 2011Article
- Proteomic analysis of HIV-infected macrophages.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Review
- The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Restricted HIV-1 replication in placental macrophages is caused by inefficient viral transcription.Journal of leukocyte biology · 2010Article
- Inhibitory effect of glycyrrhizin on the neutrophil-dependent increase of R5 HIV replication in cultures of macrophages.Immunology and cell biology · 2009Article
- Characterization of the placental macrophage secretome: implications for antiviral activity.Placenta · 2009Article
- Article
- Differential HIV-1 replication in neonatal and adult blood mononuclear cells is influenced at the level of HIV-1 gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Down-regulation of CXCR-4 and CCR-5 expression by interferon-gamma is associated with inhibition of chemotaxis and human immunodeficiency virus (HIV) replication but not HIV entry into human monocytes.Clinical and experimental immunology · 2004Article
- Anti-human immunodeficiency virus activity of tau interferon in human macrophages: involvement of cellular factors and beta-chemokines.Journal of virology · 2003Article
- CCR5 expression and beta-chemokine production during placental neonatal monocyte differentiation.Pediatric research · 2003Article
- Fcgamma receptor-mediated suppression of human immunodeficiency virus type 1 replication in primary human macrophages.Journal of virology · 2003Article
- Cell surface CCR5 density determines the postentry efficiency of R5 HIV-1 infection.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Early pathogenesis of transmucosal feline immunodeficiency virus infection.Journal of virology · 2002Article
- Production of interferons and beta-chemokines by placental trophoblasts of HIV-1-infected women.Infectious diseases in obstetrics and gynecology · 2001Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laboratory-adapted (LA) macrophage-tropic (M-tropic) human immunodeficiency virus type 1 (HIV-1) isolates (e.g., HIV-1(Ba-L)) and low-passage primary (PR) isolates differed markedly in tropism for syngeneic neonatal monocytes, monocyte-derived macrophages (MDMs), and placental macrophages (PMs). Newly adherent neonatal monocytes and cultured PMs were highly refractory to infection with PR HIV-1 isolates yet were permissive for LA M-tropic isolates. Day 4 MDMs were also permissive for LA M-tropic isolates and additionally, were permissive for over half the PR isolates tested. Qualitative differences in PR HIV-1 infection of monocytes/MDMs could not be correlated with CD4 levels alone, and in all three cell types the block to PR HIV-1 strain replication preceded reverse transcription. Neonatal monocyte susceptibility to PR HIV-1 strains correlated with increasing CCR-5 expression during maturation. CCR-5 could not be detected on newly adherent (day 1) neonatal monocytes, in contrast to adult monocytes (H. Naif et al., J. Virol. 72:830-836, 1998), but was readily detectable after 4 to 7 days of culture. However, moderate CCR-5 mRNA levels were present in day 1 neonatal monocytes and remained constant during monocyte maturation. CCR-5 was not detectable on the surface of PMs, yet the receptor was present within permeabilized cells. Notably, two brain-derived PR HIV-1 isolates from a single patient, differing in their V3 loops, were discordant in their abilities to infect neonatal monocytes/MDMs and PMs, yet both isolates could infect newly adherent adult monocytes. Together these data strongly suggest that LA HIV-1 isolates are able to infect neonatal monocytes at earlier stages of maturation and lower-level expression of CCR-5 than PR isolates. The differences between neonatal and adult monocytes in susceptibility to PR isolates may also be related to the level of CCR-5 expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.