ArticleThe Plant cell1997
The dominant developmental mutants of tomato, Mouse-ear and Curl, are associated with distinct modes of abnormal transcriptional regulation of a Knotted gene.
Article in The Plant cell, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed.
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Mapping and transcriptomic profiling reveal that the KNAT6 gene is involved in the dark green peel colour of mature pumpkin fruit (Cucurbita maxima L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Shaping leaves through TALE homeodomain transcription factors.Journal of experimental botany · 2024Review
- The developmental dynamics in cool season legumes with focus on chickpea.Plant molecular biology · 2023Review
- CLASS-II KNOX genes coordinate spatial and temporal ripening in tomato.Plant physiology · 2022Article
- Genome-wide characterization of the TALE homeodomain family and the KNOX-BLH interaction network in tomato.Plant molecular biology · 2022Article
- Trafficking and localization ofCommunicative & integrative biology · 2022Article
- Coordinating the morphogenesis-differentiation balance by tweaking the cytokinin-gibberellin equilibrium.PLoS genetics · 2021Article
- Article
- Genetic control of compound leaf development in the mungbean (Horticulture research · 2019Article
- Molecular Control by Non-coding RNAs During Fruit Development: From Gynoecium Patterning to Fruit Ripening.Frontiers in plant science · 2018Review
- Identification of phloem-mobile mRNA.Journal of plant research · 2015Review
- Regulation of Compound Leaf Development.Plants (Basel, Switzerland) · 2013Review
- A role for APETALA1/fruitfull transcription factors in tomato leaf development.The Plant cell · 2013Article
- Trifoliate encodes an MYB transcription factor that modulates leaf and shoot architecture in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- KNOX1 genes regulate lignin deposition and composition in monocots and dicots.Frontiers in plant science · 2013Article
- Auxin and LANCEOLATE affect leaf shape in tomato via different developmental processes.Plant signaling & behavior · 2012Article
- The mRNA of a Knotted1-like transcription factor of potato is phloem mobile.Plant molecular biology · 2012Article
- A comprehensive dataset of genes with a loss-of-function mutant phenotype in Arabidopsis.Plant physiology · 2012Article
- A role for PHANTASTICA in medio-lateral regulation of adaxial domain development in tomato and tobacco leaves.Annals of botany · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Curl (Cu) and Mouse-ear (Me) mutations of tomato cause two seemingly unrelated developmental syndromes with a wide range of pleiotropic phenotypes. Yet, the distinct morphogenic alterations in shoots, leaves, and inflorescences conferred by the two mutations appear to be caused by unchecked meristematic activity that characterizes dominant mutations in Knotted1 (Kn1)-like genes of monocot plants. We have been unable to separate the two closely linked Cu and Me mutations, and they may lie in the same gene. A homeobox-containing class I Kn1-like gene, TKn2, also maps to the same location. Significantly, the dominant mutations are associated with two aberrant modes of TKn2 transcription. Overexpression of the two in-frame wild-type transcripts of TKn2 is associated with the Cu mutation, whereas misexpression of an abundant and oversized fusion mRNA is associated with the Me mutation. Available molecular evidence strongly suggests that the defective Me-TKn2 transcript is generated via a novel splicing event that merges transcripts of two closely linked genes. The translated fusion product is comprised of most of the 5' end of the adjacent PPi-dependent fructose 6-phosphate phosphotransferase (PFP) transcript spliced in-frame to coding position 64 of the TKn2 transcript, leaving the TKn2 homeobox intact. We suggest that class I Kn1-like genes were selected early during evolution to regulate basic programs of aerial meristems and that subtle alterations in their function may be the basis for the wide diversity in growth parameters of shoot systems, leaves, and inflorescences among plant species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.