ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Single neuron mosaics of the drosophila gigas mutant project beyond normal targets and modify behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- The role of TSC1 and TSC2 proteins in neuronal axons.Molecular psychiatry · 2024Review
- The gut-microbiota-brain axis in autism: what Drosophila models can offer?Journal of neurodevelopmental disorders · 2021Review
- In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome.Frontiers in cellular neuroscience · 2015Article
- Structural and functional analysis of single neurons to correlate synaptic connectivity with grooming behavior.Nature protocols · 2014Article
- Review
- Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting.Nature neuroscience · 2013Article
- Opposing roles of PlexinA and PlexinB in axonal branch and varicosity formation.Molecular brain · 2011Article
- Article
- Drosophila as a genetic and cellular model for studies on axonal growth.Neural development · 2007Review
- Article
- A meeting to remember: meeting on memory and related disorders.EMBO reports · 2006Review
- Molecular and comparative genetics of mental retardation.Genetics · 2004Article
- Cell-autonomous mechanisms and myelin-associated factors contribute to the development of Purkinje axon intracortical plexus in the rat cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling.Genes & development · 2002Article
- Increasing the number of synapses modifies olfactory perception in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- The kakapo mutation affects terminal arborization and central dendritic sprouting of Drosophila motorneurons.The Journal of cell biology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
gigas is a lethal mutant that differentiates enlarged cells, including the nucleus. This trait manifests only after the completion of the mitotic program. We have taken advantage of this phenotype to test in vivo the capacity of normal target cells to arrest the growth of mutant sensory axons. Single neuron connectivity changes have been analyzed in mosaics after horseradish peroxidase retrograde tracings. A mutant mechanoreceptor neuron, growing over a genetically normal substrate, contacts its normal target, and in addition projects to novel areas of the CNS. The mutant axon does terminate its growth eventually, and the new additional targets that are reached correspond to mechanoreceptor domains in other ganglia, indicating that this territorial constraint is operational in the mutant. gigas neurons maintain their stereotyped profile and represent an expanded version of the normal branching pattern. The ultrastructure of the invading projections does not reveal gliotic or necrotic reactions from the new cell contacts. The functional consequences of the connectivity changes produced by the mutant mechanoreceptors have been studied in grooming behavior. Mosaic flies carrying a single gigas mechanoreceptor show modified, albeit context-coherent, grooming responses after stimulation of the mutant bristle, whereas the response from neighboring normal sensory neurons remains unchanged. All of these experiments indicate that target recognition and growth arrest are two dissectible processes of neural development, and they highlight the autonomous features of the growth cone during pathfinding.
Indexed as
Identifiers
9437021PMC6792781What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.