ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Transport and turnover of microtubules in frog neurons depend on the pattern of axonal growth.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Understanding, engineering, and modulating the growth of neural networks: An interdisciplinary approach.Biophysics reviews · 2021Review
- Dynein-mediated microtubule translocation powering neurite outgrowth in chick andJournal of cell science · 2020Article
- Neurite elongation is highly correlated with bulk forward translocation of microtubules.Scientific reports · 2017Article
- A mathematical model explains saturating axon guidance responses to molecular gradients.eLife · 2016Article
- Xenopus cytoplasmic linker-associated protein 1 (XCLASP1) promotes axon elongation and advance of pioneer microtubules.Molecular biology of the cell · 2013Article
- Drosophila growth cones advance by forward translocation of the neuronal cytoskeletal meshwork in vivo.PloS one · 2013Article
- The emerging role of forces in axonal elongation.Progress in neurobiology · 2011Review
- The role of stretching in slow axonal transport.Biophysical journal · 2011Article
- The glucuronyltransferase GlcAT-P is required for stretch growth of peripheral nerves in Drosophila.PloS one · 2011Article
- Slowing of axonal regeneration is correlated with increased axonal viscosity during aging.BMC neuroscience · 2010Article
- A physical model of axonal elongation: force, viscosity, and adhesions govern the mode of outgrowth.Biophysical journal · 2008Article
- Direct evidence for coherent low velocity axonal transport of mitochondria.The Journal of cell biology · 2006Article
- Live-cell imaging of slow axonal transport in cultured neurons.Methods in cell biology · 2003Article
- Growth cone turning induced by direct local modification of microtubule dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Rapid intermittent movement of axonal neurofilaments observed by fluorescence photobleaching.Molecular biology of the cell · 2001Article
- Neurofilaments are transported rapidly but intermittently in axons: implications for slow axonal transport.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Reorganization and movement of microtubules in axonal growth cones and developing interstitial branches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Different contributions of microtubule dynamics and transport to the growth of axons and collateral sprouts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Slow axonal transport of neurofilament protein in cultured neurons.The Journal of cell biology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The transport of axonal microtubules in growing neurites has been a controversial issue because of clear but conflicting results obtained with fluorescence-marking techniques. We have attempted to resolve the discordance via analysis of the relationship between apparent microtubule translocation and cell adhesion. Neuronal cultures were prepared from Xenopus embryos 1 d after injection of Cy3-conjugated tubulin into one of the blastomeres of two-cell-stage embryos. Anterograde translocation of axonal microtubules was observed in neurons cultured on a laminin-coated surface, in agreement with previously published data for Xenopus embryonic neurons. However, when neuronal cultures were prepared on a concanavalin A-treated surface, the axonal microtubules were stationary, as reported for all other neurons investigated previously. Neuronal cultures prepared on laminin- and concanavalin A-coated surfaces also demonstrated dramatic differences in the pattern of axonal growth, dynamics of axonal microtubules, and response to brefeldin A treatment. Our findings suggest that transport and dynamics of axonal microtubules may be directly affected by the mechanical tension produced by growth cone activity.
Indexed as
Identifiers
9437004PMC6792771W1518239715What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.