ArticleGenes & development1998
DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila.
Article in Genes & development, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
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Who cites it
130 citing papers in PubMed, 310 citations in OpenAlex.
- Harnessing the Power ofCold Spring Harbor perspectives in biology · 2026Review
- RhoGEF2 overexpression induces cell competition dependent on Ptp10D, Crumbs and the Hippo signaling pathway.Journal of cell science · 2025Article
- Endogenous OptoRhoGEFs reveal biophysical principles of epithelial tissue furrowing.Nature communications · 2025Article
- The RhoGEF protein Plekhg5 self-associates via its PH domain to regulate apical cell constriction.Molecular biology of the cell · 2024Article
- Structured RhoGEF recruitment drives myosin II organization on large exocytic vesicles.Journal of cell science · 2024Article
- Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila.Current biology : CB · 2024Article
- Embryonic spatiotemporal expression pattern of Folded gastrulation suggests roles in multiple morphogenetic events and regulation by AbdA.G3 (Bethesda, Md.) · 2024Article
- Medioapical contractile pulses coordinated between cells regulate Drosophila eye morphogenesis.The Journal of cell biology · 2024Article
- Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability inbioRxiv : the preprint server for biology · 2023Article
- Actomyosin pulsing rescues embryonic tissue folding from disruption by myosin fluctuations.Research square · 2023Article
- The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin dynamics of apical constriction duringMolecular biology of the cell · 2023Article
- The α-Catenin mechanosensing M region is required for cell adhesion during tissue morphogenesis.The Journal of cell biology · 2023Article
- An AMPK phosphoregulated RhoGEF feedback loop tunes cortical flow-driven amoeboid migration in vivo.Science advances · 2022Article
- The cell polarity determinant Dlg1 facilitates epithelial invagination by promoting tissue-scale mechanical coordination.Development (Cambridge, England) · 2022Article
- Optogenetic inhibition of actomyosin reveals mechanical bistability of the mesoderm epithelium duringeLife · 2022Article
- Evidence for a Role of the Lateral Ectoderm inFrontiers in cell and developmental biology · 2022Article
- Toll-Dorsal signaling regulates the spatiotemporal dynamics of yolk granule tubulation during Drosophila cleavage.Developmental biology · 2022Article
- Using optogenetics to link myosin patterns to contractile cell behaviors during convergent extension.Biophysical journal · 2021Article
- Isoform-specific roles of the Drosophila filamin-type protein Jitterbug (Jbug) during development.Genetics · 2021Article
- MRCK: a master regulator of tissue remodeling or another 'ROCK' in the epithelial block?Tissue barriers · 2021Review
70 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified a gene, DRhoGEF2, which encodes a putative guanine nucleotide exchange factor belonging to the Dbl family of oncogenes. DRhoGEF2 function is essential for the coordination of cell shape changes during gastrulation. In the absence of maternal DRhoGEF2 gene activity, mesodermal and endodermal primordia fail to invaginate. The phenotype seen in DRhoGEF2 mutants is more severe than the defects associated with mutations in two previously identified gastrulation genes, folded gastrulation and concertina, suggesting that DRhoGEF2 acts in a signaling pathway independent of these genes. Expression of dominant-negative DRhoA during gastrulation results in phenocopies of the DRhoGEF2 mutant, suggesting that a signaling cascade involving DRhoGEF2 and the small GTPase DRhoA is responsible for the regulation of cell shape changes during early Drosophila morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.