ArticleJournal of neurology, neurosurgery, and psychiatry1998
Diagnostic value of sural nerve biopsy in chronic inflammatory demyelinating polyneuropathy.
Article in Journal of neurology, neurosurgery, and psychiatry, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy.The Cochrane database of systematic reviews · 2024Pooled it
- Diagnostic value of proximal cutaneous nerve biopsy in brachial and lumbosacral plexus pathologies.Acta neurochirurgica · 2023Article
- Relevance of Nerve Biopsy in the Diagnosis of Chronic Inflammatory Demyelinating Polyneuropathy-Diagnostics (Basel, Switzerland) · 2022Review
- Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy.Brain : a journal of neurology · 2020Review
- The first report of pure neuritic leprosy with involvement of the anterior femoral cutaneous nerve.Neurology international · 2019Article
- Chronic inflammatory demyelinating polyneuropathy.Current treatment options in neurology · 2013Article
- Multifocal motor neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, and other chronic acquired demyelinating polyneuropathy variants.Neurologic clinics · 2013Review
- Effect of age on the fractional anisotropy (FA) value of peripheral nerves and clinical significance of the age-corrected FA value for evaluating polyneuropathies.Neuroradiology · 2012Article
- Diagnostic approach to peripheral neuropathy.Annals of Indian Academy of Neurology · 2008Article
- Clinical evaluation and investigation of neuropathy.Journal of neurology, neurosurgery, and psychiatry · 2003Article
- Review
- Current concepts and controversy in chronic inflammatory demyelinating polyneuropathy.Current neurology and neuroscience reports · 2003Review
- Diagnostic investigation of patients with chronic polyneuropathy: evaluation of a clinical guideline.Journal of neurology, neurosurgery, and psychiatry · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the additional diagnostic value of sural nerve biopsy of 64 patients in whom chronic inflammatory demyelinating polyneuropathy (CIDP) was considered, as sural nerve biopsy is recommended in the research criteria of an ad hoc subcommittee to diagnose CIDP.
methodsFirstly, the additional diagnostic value of sural nerve biopsy was analysed with multivariate logistic regression. Six clinical features (remitting course, symmetric sensorimotor neuropathy in arms and legs, areflexia, raised CSF protein concentration, nerve conduction studies consistent with demyelination, and absence of comorbidity or relevant laboratory abnormalities) were entered into a logistic model. Afterwards, all significant features identified from this model, as well as the results of sural nerve biopsy were forced into a second logistic model. Secondly, the diagnostic performance of a neurologist experienced in diagnosis of peripheral nerve disorders was studied by receiver operating characteristics (ROC) curve analysis.
resultsThe results of the first logistic analysis showed that CSF protein concentration >1 g/l (odds ratio (OR)=38.5) and neurophysiological studies consistent with demyelination (OR=51.7) were strong predictors of CIDP. When forcing the significant features and the sural nerve biopsy data into the model, an independent predictive value of sural nerve biopsy could not be found. The neurologist was able to discriminate patients with and without CIDP (area under the curve (AUC)=0.95). His diagnostic performance did not improve significantly by offering him the results of sural nerve biopsy.
conclusionAny additional diagnostic value of sural nerve biopsy in the diagnosis of CIDP could not be shown.
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Registered trials
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