ArticleProceedings of the National Academy of Sciences of the United States of America1998
Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- A globally applicable PCR-based detection and discrimination of BK and JC polyomaviruses.Revista do Instituto de Medicina Tropical de Sao Paulo · 2018Article
- Expression pattern of neuronal intermediate filament α-internexin in anterior pituitary gland and related tumors.Pituitary · 2015Article
- Tax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation.Frontiers in microbiology · 2013Article
- The HTLV-1 Tax interactome.Retrovirology · 2008Review
- Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Muscle wasting induced by HTLV-1 tax-1 protein: an in vitro and in vivo study.The American journal of pathology · 2005Article
- Deregulation of cell-signaling pathways in HTLV-1 infection.Oncogene · 2005Review
- SR-related protein TAXREB803/SRL300 is an important cellular factor for the transactivational function of human T-cell lymphotropic virus type 1 Tax.Journal of virology · 2003Article
- Congruence of tissue expression profiles from Gene Expression Atlas, SAGEmap and TissueInfo databases.BMC genomics · 2003Article
- The role of human T-lymphotropic virus type 1 (HTLV-1)-infected dendritic cells in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis.Journal of virology · 1999Article
- CREB-2, a cellular CRE-dependent transcription repressor, functions in association with Tax as an activator of the human T-cell leukemia virus type 1 promoter.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The human T-cell leukemia virus (HTLV) is associated with adult T cell leukemia and neurological disorders (TSP/HAM). The HTLV transcriptional transactivator, Tax, is known to exert its effect through protein-protein interaction with several transcription factors that activate genes in T cell proliferation. The pathogenic mechanism in the CNS is less defined. Using the yeast two-hybrid system, we have identified a specific Tax-binding protein as the neuronal specific intermediate filament protein, alpha-internexin. Tax binds to the domain corresponding to the rod region of alpha-internexin, which is essential for neurofilament assembly. The Tax domains involved in binding are separable from those involved in transactivation. TxBP-1/alpha-internexin and Tax are expressed in the cytoplasm and nucleus, respectively, when expressed alone, but in coexpressing cells, colocalization of both proteins was observed in a perinuclear, punctate distribution. This in vivo interaction also resulted in a dramatic reduction in Tax transactivation and the network formation by alpha-internexin. The specific interaction of Tax and a neuronal specific intermediate filament protein may provide a clue to the pathogenesis of TSP/HAM.
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