ArticleProceedings of the National Academy of Sciences of the United States of America1998
Rapid noninvasive detection of experimental atherosclerotic lesions with novel 99mTc-labeled diadenosine tetraphosphates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 49 citations in OpenAlex.
- Pre-clinical and clinical evaluation of nuclear tracers for the molecular imaging of vulnerable atherosclerosis: an overview.Current medicinal chemistry · 2009Review
- Article
- P2 receptors in atherosclerosis and postangioplasty restenosis.Purinergic signalling · 2007Article
- Detection of inflamed atherosclerotic lesions with diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) and positron-emission tomography.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- P2 receptors in atherosclerosis and postangioplasty restenosis.Purinergic signalling · 2006Article
- Evaluation of 99mTc labeled diadenosine tetraphosphate as an atherosclerotic plaque imaging agent in experimental models.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2006Article
- Molecular imaging of atherosclerotic plaques with technetium-99m-labelled antisense oligonucleotides.European journal of nuclear medicine and molecular imaging · 2005Article
- Progression of detail.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2000Article
- Radionuclide imaging probes for expressed proteins.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
- Atherosclerosis imaging on the molecular level.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
- Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques.Korean journal of radiologyReview
- Proceedings of the 4th Invitational Wintergreen Conference. Wintergreen, Virginia, USA. July 12-14, 1998. Abstracts.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Strategic targeting of atherosclerotic lesions.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Second Annual Mario S. Verani, MD, Memorial Lecture: Nuclear cardiology, the next 10 years.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of a noninvasive imaging procedure for identifying atherosclerotic lesions is extremely important for the clinical management of patients with coronary artery and peripheral vascular disease. Although numerous radiopharmaceuticals have been proposed for this purpose, none has demonstrated the diagnostic accuracy required to replace invasive angiography. In this report, we used the radiolabeled purine analog, 99mTc diadenosine tetraphosphate (Ap4A; AppppA, P1,P4-di(adenosine-5')-tetraphosphate) and its analogue 99mTc AppCHClppA for imaging experimental atherosclerotic lesions in New Zealand White rabbits. Serial gamma camera images were obtained after intravenous injection of the radiolabeled dinucleotides. After acquiring the final images, the animals were sacrificed, ex vivo images of the aortas were recorded, and biodistribution was measured. 99mTc-Ap4A and 99mTc AppCHClppA accumulated rapidly in atherosclerotic abdominal aorta, and lesions were clearly visible within 30 min after injection in all animals that were studied. Both radiopharmaceuticals were retained in the lesions for 3 hr, and the peak lesion to normal vessel ratio was 7.4 to 1. Neither of the purine analogs showed significant accumulation in the abdominal aorta of normal (control) rabbits. The excised aortas showed lesion patterns that were highly correlated with the in vivo and ex vivo imaging results. The present study demonstrates that purine receptors are up-regulated in experimental atherosclerotic lesions and 99mTc-labeled purine analogs have potential for rapid noninvasive detection of plaque formation.
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