ArticleProceedings of the National Academy of Sciences of the United States of America1998
Inability of keratinocytes lacking their specific transglutaminase to form cross-linked envelopes: absence of envelopes as a simple diagnostic test for lamellar ichthyosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 44 citations in OpenAlex.
- A cellular disease model toward gene therapy ofMolecular therapy. Methods & clinical development · 2024Article
- Oxidative stress in aging human skin.Biomolecules · 2015Review
- Inherited ichthyoses/generalized Mendelian disorders of cornification.European journal of human genetics : EJHG · 2013Review
- Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function.The American journal of pathology · 2011Article
- The clinical and morphologic features of nonepidermolytic ichthyosis in the golden retriever.Veterinary pathology · 2008Article
- Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders.Advances in dermatology · 2007Review
- A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytes.BMC dermatology · 2004Article
- Targeted ablation of the murine involucrin gene.The Journal of cell biology · 2000Article
- Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein.The Journal of cell biology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidermal keratinocytes, late in their terminal differentiation, form cross-linked envelopes resistant to ionic detergent and reducing agent. Because the cross-linking process is catalyzed by the keratinocyte transglutaminase, the absence of active transglutaminase should result in failure of the keratinocyte to form a cross-linked envelope. Three keratinocyte strains bearing mutations in the keratinocyte transglutaminase were examined: two contained no detectable transglutaminase mRNA and none contained active enzyme. All three were unable to form cross-linked envelopes, either spontaneously in stratified cultures or upon induction with Ca2+. Although stratum corneum of normal humans and scales from patients with different ichthyotic diseases contain cross-linked envelopes, those from patients with transglutaminase-negative lamellar ichthyosis do not. Therefore, the disease due to the absence of transglutaminase may be readily distinguished from other ichthyotic disease by a simple test for cross-linked envelopes.
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Registered trials
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