ArticleEnvironmental health perspectives1998
Models of interaction between metabolic genes and environmental exposure in cancer susceptibility.
Article in Environmental health perspectives, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pooled analysis of the HLA-DRB1 by smoking interaction in Parkinson disease.Annals of neurology · 2017Pooled it
- The synergic effects of CTLA-4/Foxp3-related genotypes and chromosomal aberrations on the risk of recurrent spontaneous abortion among a Chinese Han population.Journal of human genetics · 2018Article
- Association between cooking oil fume exposure and lung cancer among Chinese nonsmoking women: a meta-analysis.OncoTargets and therapy · 2016Article
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- Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk.Journal of the National Cancer Institute · 2011Article
- Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer.World journal of gastroenterology · 2010Article
- Gene-environment interaction in tobacco-related cancers.Carcinogenesis · 2008Review
- A model of gene-gene and gene-environment interactions and its implications for targeting environmental interventions by genotype.Theoretical biology & medical modelling · 2006Article
- Interaction models of CYP1A1, GSTM1 polymorphisms and tobacco smoking in intestinal gastric cancer.World journal of gastroenterology · 2005Article
- A novel genetic polymorphism of inducible nitric oxide synthase is associated with an increased risk of gastric cancer.World journal of gastroenterology · 2004Article
- Risk of childhood leukemia associated with diagnostic irradiation and polymorphisms in DNA repair genes.Environmental health perspectives · 2000Article
- Bone mineral density and gene-environment interactions in the search for osteoporosis genes.Environmental health perspectives · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Polymorphic metabolic genes that confer enhanced genetic susceptibility to the carcinogenic effects of certain environmental carcinogens act according to a type 2 interaction between genetic and environmental risk factors. This type of interaction, for which the gene has no effect on disease outcome by itself but only modifies the risk associated with exposure, must be treated differently from other types of gene-environment interaction. We present a method to analyze different dose effects often seen in studies involving these genes. We define a low exposure-gene effect, when a greater degree of gene environment interaction appears at lower doses of exposure (the interaction follows an inverse dose function), and a converse high exposure-gene effect, when the interaction increases as a function of dose. Using a standard logistic regression model, we define a new term, alpha, that can be determined asa function of exposure dose in order to analyze epidemiological studies for the type of exposure-gene effect. These models are illustrated by the use of hypothetical case-control data as well as examples from the literature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.