ArticleMammalian genome : official journal of the International Mammalian Genome Society1998
Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 36 citations in OpenAlex.
- The biochemistry of melanogenesis: an insight into the function and mechanism of melanogenesis-related proteins.Frontiers in molecular biosciences · 2024Review
- Article
- Mutational analysis of oculocutaneous albinism: a compact review.BioMed research international · 2014Review
- In silico screening and molecular dynamics simulation of disease-associated nsSNP in TYRP1 gene and its structural consequences in OCA3.BioMed research international · 2013Article
- L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions.Pigment cell & melanoma research · 2012Review
- Tyrosinase related protein 1 (TYRP1/gp75) in human cutaneous melanoma.Molecular oncology · 2011Review
- Oculocutaneous albinism.Orphanet journal of rare diseases · 2007Review
- Genetic and in silico comparative mapping of the polyphenol oxidase gene in bread wheat (Triticum aestivum L.).Functional & integrative genomics · 2005Article
- Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals.International immunology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complete 24,667 nucleotide sequence spanning the human TYRP1 gene has been determined from the inserts of two overlapping lambda clones. A LINE-1 repeat element is immediately adjacent to and may demarcate the immediate 5' promoter region of the gene. A search for polymorphism within the seven TYRP1 coding exons has been performed by an RNase mismatch detection procedure. Analysis of the TYRP1 gene in 100 Caucasian individuals of varying hair color has found no amino acid sequence variation nor revealed any hemizygous mutant allele in the hypopigmented phenotype of two 9p- syndrome patients.
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Registered trials
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