ArticleMammalian genome : official journal of the International Mammalian Genome Society1998
IRS-PCR-based genetic mapping of the huntingtin interacting protein gene (HIP1) on mouse chromosome 5.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 14 citations in OpenAlex.
- Mobilization and evolutionary history of miniature inverted-repeat transposable elements (MITEs) in Beta vulgaris L.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2006Article
- Advanced integrated mouse YAC map including BAC framework.Genome research · 2001Article
- UniGene cDNA array-based monitoring of transcriptome changes during mouse placental development.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Huntington's disease: from gene to potential therapy.Dialogues in clinical neuroscience · 2001Article
- Interspersed repetitive sequence (IRS)-PCR for typing of whole genome radiation hybrid panels.Nucleic acids research · 2000Article
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6 authors at 1 institution in 1 country.
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Abstract
Huntington's disease (HD) is a devastating central nervous system disorder. Even though the gene responsible has been positionally cloned recently, its etiology has remained largely unclear. To investigate potential disease mechanisms, we conducted a search for binding partners of the HD-protein huntingtin. With the yeast two-hybrid system, one such interacting factor, the huntingtin interacting protein-1 (HIP-1), was identified (Wanker et al. 1997; Kalchman et al. 1997) and the human gene mapped to 7q11.2. In this paper we demonstrate the localization of the HIP1 mouse homologue (Hip1) into a previously identified region of human-mouse synteny on distal mouse Chromosome (Chr) 5, both employing an IRS-PCR-based mapping strategy and traditional fluorescent in situ hybridization (FISH) mapping.
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