ReviewPharmaceutical research1997
Functional and molecular characteristics of Na(+)-dependent nucleoside transporters.
Review in Pharmaceutical research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Pharmacogenetics and pharmacoepigenetics of gemcitabine.Medical oncology (Northwood, London, England) · 2010Review
- Modeling kinetics of subcellular disposition of chemicals.Chemical reviews · 2009Review
- Imatinib-resistant CML cells have low ENT activity but maintain sensitivity to gemcitabine.Nucleosides, nucleotides & nucleic acids · 2008Article
- Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1.The Biochemical journal · 2004Article
- ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors.Molecular and cellular biology · 2004Article
- Nucleoside transporters in chronic lymphocytic leukaemia.Leukemia · 2004Review
- Genomic organization and functional characterization of the human concentrative nucleoside transporter-3 isoform (hCNT3) expressed in mammalian cells.Pflugers Archiv : European journal of physiology · 2003Article
- Hypoxanthine transport in human glioblastoma cells and effect on cell susceptibility to methotrexate.Pharmaceutical research · 2003Article
- Sodium dependence of nitrofurantoin active transport across mammary epithelia and effects of dipyridamole, nucleosides, and nucleobases.Pharmaceutical research · 2002Article
- Extracellular formation and uptake of adenosine during skeletal muscle contraction in the rat: role of adenosine transporters.The Journal of physiology · 2001Article
- Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissues.AAPS pharmSci · 2001Article
- Contribution of the nucleoside transport system to doxorubicin transport in HL60 cells but not in mononuclear cells.Japanese journal of cancer research : Gann · 1999Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Nucleoside transporters play a critical role in the absorption, disposition, and targeting of therapeutically used nucleosides and nucleoside analogs. This review is focused on the Na(+)-dependent, concentrative nucleoside transporters which are found in a variety of cells including renal, intestinal and hepatic epithelia. Five major Na(+)-dependent nucleoside transporter subtypes have been characterized in isolated tissue preparations: N1 is purine selective; N2 is pyrimidine selective and N3-N5 exhibit variable selectively for both purine and pyrimidine nucleosides. The recent cloning of N1 and N2 nucleoside transporters has provided the first information on the molecular function and structure of concentrative nucleoside transporters. In this manuscript we review the characteristics of the various subtypes of nucleoside transporters and the molecular structure, functional properties, and tissue distribution of the cloned Na(+)-dependent nucleoside transporters. In addition, the interactions of nucleosides and nucleoside analogs with the cloned transporters in mammalian and amphibian expression systems are presented. Mammalian expression systems may be particularly useful during drug development in screening potential compounds for improved bioavailability and tissue specific targeting. Finally, we present our view of future ares of study in the field of nucleoside transporters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.