ArticleThe Journal of experimental medicine1998
Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 220 citations in OpenAlex.
- Interleukin-10 augments human endogenous retroviral E1B variant of cd5 in aged T cells.Blood research · 2025Article
- Role of Exercise Intensity on Th1/Th2 Immune Modulations During the COVID-19 Pandemic.Frontiers in immunology · 2021Review
- Conversion of Anergic T Cells Into Foxp3Frontiers in immunology · 2021Article
- Anergy into T regulatory cells: an integration of metabolic cues and epigenetic changes at the Foxp3 conserved non-coding sequence 2.F1000Research · 2018Review
- Mechanisms of Tolerance Induction by Dendritic CellsFrontiers in immunology · 2018Review
- Metastatic colon adenocarcinoma has a significantly elevated expression of IL-10 compared with primary colon adenocarcinoma tumors.Cancer biology & therapy · 2018Article
- Induction of CD4(+) Regulatory and Polarized Effector/helper T Cells by Dendritic Cells.Immune network · 2016Review
- Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity.Frontiers in immunology · 2015Review
- Current status of interleukin-10 and regulatory T-cells in cancer.Current opinion in oncology · 2013Review
- Expression and secretion levels of Th1 and Th2 cytokines in patients with aggressive periodontitis.Clinical oral investigations · 2012Article
- Age-related accumulation of T cells with markers of relatively stronger autoreactivity leads to functional erosion of T cells.BMC immunology · 2012Article
- Interleukin-10 receptor expression and signalling were down-regulated in CD4⁺ T cells of lupus nephritis patients.Clinical and experimental immunology · 2011Article
- Expression of 3G11 epitope defines subpopulations of regulatory T cells with different suppressive potency.Journal of the neurological sciences · 2010Article
- Allergen-specific subcutaneous immunotherapy in allergic asthma: immunologic mechanisms and improvement.The Libyan journal of medicine · 2010Article
- Isolation and characterization of human interleukin-10-secreting T cells from peripheral blood.Human immunology · 2010Article
- The anti-inflammatory limb of the immune response in preterm labor, intra-amniotic infection/inflammation, and spontaneous parturition at term: a role for interleukin-10.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2008Article
- Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease?Journal of inflammation (London, England) · 2008Article
- CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Natural and induced regulatory T cells: targets for immunotherapy of autoimmune disease and allergy.Inflammation & allergy drug targets · 2006Review
- Signatures of human regulatory T cells: an encounter with old friends and new players.Genome biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous antigenic stimulation in vivo can result in the generation of so-called "anergic" CD4(+) or CD8(+) T cells that fail to proliferate upon antigenic stimulation and fail to develop cytolytic effector functions. Here we show that class II major histocompatibility complex-restricted T cells specific for influenza hemagglutinin (HA) that become anergic in mice expressing HA under control of the immunoglobulin kappa promoter exhibit an impaired effector function in causing diabetes in vivo, as compared to their naive counterparts, when transferred into immunodeficient recipients expressing HA under the control of the insulin promoter. Furthermore, HA-specific T cells anergized in vivo contain higher levels of interleukin (IL)-4 messenger RNA (mRNA) than naive and recently activated T cells with the same specificity and more than a 100-fold higher levels of IL-10 mRNA. The higher expression of the IL-10 gene is also evident at the protein level. These findings raise the interesting possibility that T cells rendered anergic in vivo have in fact become regulatory T cells that may influence neighboring immune responses through the release of IL-10.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.