ArticleThe EMBO journal1998
Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 162 citations in OpenAlex.
- The dual function model revisited by thyroid hormone receptor knockouts: Unliganded state controlling the initiation of adult organ development while liganded state ensuring larval tissue resorption during metamorphosis.Developmental biology · 2026Review
- Functions and Mechanism of Thyroid Hormone Receptor Action During Amphibian Development.Endocrinology · 2024Review
- Life Without Thyroid Hormone Receptor.Endocrinology · 2021Review
- Epigenetic Modifications and Therapy in Uveitis.Frontiers in cell and developmental biology · 2021Review
- The development of adult intestinal stem cells: Insights from studies on thyroid hormone-dependent anuran metamorphosis.Vitamins and hormones · 2021Article
- The Histone Modifications of Neuronal Plasticity.Neural plasticity · 2021Review
- Thyroid hormone activatesFrontiers in bioscience (Landmark edition) · 2020Article
- A unique role of thyroid hormone receptor β in regulating notochord resorption during Xenopus metamorphosis.General and comparative endocrinology · 2019Article
- Involvement of epigenetic modifications in thyroid hormone-dependent formation of adult intestinal stem cells during amphibian metamorphosis.General and comparative endocrinology · 2019Article
- Thyroid hormone regulation of adult intestinal stem cells: Implications on intestinal development and homeostasis.Reviews in endocrine & metabolic disorders · 2016Review
- A Quantitative Proteomic Analysis of In Vitro Assembled Chromatin.Molecular & cellular proteomics : MCP · 2016Article
- Regulation of growth rate and developmental timing by Xenopus thyroid hormone receptor α.Development, growth & differentiation · 2016Review
- Epigenetic regulation of thyroid hormone-induced adult intestinal stem cell development during anuran metamorphosis.Cell & bioscience · 2014Review
- Unliganded thyroid hormone receptor regulates metamorphic timing via the recruitment of histone deacetylase complexes.Current topics in developmental biology · 2013Review
- Thyroid hormone receptor actions on transcription in amphibia: The roles of histone modification and chromatin disruption.Cell & bioscience · 2012Article
- Chromatin-mediated regulation of cytomegalovirus gene expression.Virus research · 2011Review
- AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function.Cell research · 2010Article
- Dual functions of thyroid hormone receptors in vertebrate development: the roles of histone-modifying cofactor complexes.Thyroid : official journal of the American Thyroid Association · 2009Review
- Article
- Regulation of P-TEFb elongation complex activity by CDK9 acetylation.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone deacetylase and chromatin assembly contribute to the control of transcription of the Xenopus TRbetaA gene promoter by the heterodimer of Xenopus thyroid hormone receptor and 9-cis retinoic acid receptor (TR-RXR). Addition of the histone deacetylase inhibitor Trichostatin A (TSA) relieves repression of transcription due to chromatin assembly following microinjection of templates into Xenopus oocyte nuclei, and eliminates regulation of transcription by TR-RXR. Expression of Xenopus RPD3p, the catalytic subunit of histone deacetylase, represses the TRbetaA promoter, but only after efficient assembly of the template into nucleosomes. In contrast, the unliganded TR-RXR represses templates only partially assembled into nucleosomes; addition of TSA also relieves this transcriptional repression. This result indicates the distinct requirements for chromatin assembly in mediating transcriptional repression by the deacetylase alone, compared with those needed in the presence of unliganded TR-RXR. In addition, whereas hormone-bound TR-RXR targets chromatin disruption as assayed through changes in minichromosome topology and loss of a regular nucleosomal ladder on micrococcal nuclease digestion, addition of TSA relieves transcriptional repression but does not disrupt chromatin. Thus, TR-RXR can facilitate transcriptional repression in the absence of hormone through mechanisms in addition to recruitment of deacetylase, and disrupts chromatin structure through mechanisms in addition to the inhibition or release of deacetylase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.