ReviewJournal of muscle research and cell motility1997
The membrane-cytoskeleton interface: the role of dystrophin and utrophin.
Review in Journal of muscle research and cell motility, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 88 citations in OpenAlex.
- Multiple modes of AFM reveal distinct mechanical properties for dystrophin and utrophin not manifest by small fragments.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Dystrophin and utrophin "double knockout" dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2013Article
- A molecular trajectory of α-actinin activation.Biophysical journal · 2012Article
- Fetal microchimeric cells in a fetus-treats-its-mother paradigm do not contribute to dystrophin production in serially parous mdx females.Stem cells and development · 2012Article
- Gene replacement therapies for duchenne muscular dystrophy using adeno-associated viral vectors.Current gene therapy · 2012Review
- Dystroglycan is involved in skin morphogenesis downstream of the Notch signaling pathway.Molecular biology of the cell · 2011Article
- Biomechanics of the sarcolemma and costameres in single skeletal muscle fibers from normal and dystrophin-null mice.Journal of muscle research and cell motility · 2011Article
- Tissue expression and actin binding of a novel N-terminal utrophin isoform.Journal of biomedicine & biotechnology · 2011Article
- Dystroglycan versatility in cell adhesion: a tale of multiple motifs.Cell communication and signaling : CCS · 2010Article
- Dystrophins, utrophins, and associated scaffolding complexes: role in mammalian brain and implications for therapeutic strategies.Journal of biomedicine & biotechnology · 2010Review
- Truncated dystrophins can influence neuromuscular synapse structure.Molecular and cellular neurosciences · 2009Article
- ZZ domain of dystrophin and utrophin: topology and mapping of a beta-dystroglycan interaction site.The Biochemical journal · 2007Article
- Absence of Dp71 in mdx3cv mouse spermatozoa alters flagellar morphology and the distribution of ion channels and nNOS.Journal of cell science · 2005Article
- Long-term expression of full-length human dystrophin in transgenic mdx mice expressing internally deleted human dystrophins.Gene therapy · 2004Article
- Formation of multiple complexes between beta-dystroglycan and dystrophin family products.Journal of muscle research and cell motility · 2003Article
- Utrophin binds laterally along actin filaments and can couple costameric actin with sarcolemma when overexpressed in dystrophin-deficient muscle.Molecular biology of the cell · 2002Article
- Brain dystrophin-glycoprotein complex: persistent expression of beta-dystroglycan, impaired oligomerization of Dp71 and up-regulation of utrophins in animal models of muscular dystrophy.BMC cell biology · 2001Article
- Immune responses to dystropin: implications for gene therapy of Duchenne muscular dystrophy.Gene therapy · 2000Article
- The artificial zinc finger coding gene 'Jazz' binds the utrophin promoter and activates transcription.Gene therapy · 2000Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Recent studies with transgenic animals have considerably advanced our knowledge of the roles of dystrophin and utrophin in both muscle and non-muscle tissues. Rigorous analyses of the roles of the various mdx mutations in mice, as well as the use of artificial transgenes in an mdx background, are beginning to define the functional importance of various regions of the dystrophin protein in normal muscle. Furthermore, recent biochemical analyses have revealed new insights into the role and organization of dystrophin at the membrane-cytoskeleton interface. Transgenic approaches have also revealed surprising and encouraging results with respect to utrophin. Against expectations, the long-awaited utrophin knockout mice have a remarkably mild phenotype with only subtle changes in neuromuscular junction architecture. On the other hand, mdx mice transgenic for a mini-utrophin construct showed rescue of the muscular dystrophy phenotype, clearly an encouraging finding with obvious therapeutic possibilities. These and other recent findings are discussed in the context of the structure and function of dystrophin and utrophin at the membrane-cytoskeleton interface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.