ArticleThe Journal of cell biology1998
Signaling and adhesion activities of mammalian beta-catenin and plakoglobin in Drosophila.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
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- Complementary volume electron microscopy-based approaches reveal ultrastructural changes in germline intercellular bridges.Journal of cell science · 2026Article
- AbioRxiv : the preprint server for biology · 2026Article
- Peripodial adherens junctions regulate Ajuba-Yorkie signaling to preserve fly eye morphology.Biology open · 2023Article
- Armadillo regulates nociceptive sensitivity in the absence of injury.Molecular pain · 2022Article
- The Arp2/3 complex and the formin, Diaphanous, are both required to regulate the size of germline ring canals in the developing egg chamber.Developmental biology · 2020Article
- The Misshapen kinase regulates the size and stability of the germline ring canals in the Drosophila egg chamber.Developmental biology · 2018Article
- Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis.Oncotarget · 2017Review
- Drosophila E-cadherin is required for the maintenance of ring canals anchoring to mechanically withstand tissue growth.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Wingless/Wnt signal transduction requires distinct initiation and amplification steps that both depend on Arrow/LRP.Developmental biology · 2007Article
- Etiopathogenesis of arrhythmogenic right ventricular cardiomyopathy.Journal of human genetics · 2005Review
- Article
- Cadherin sequences that inhibit beta-catenin signaling: a study in yeast and mammalian cells.Molecular biology of the cell · 2001Article
- Article
- Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity.The EMBO journal · 2000Article
- Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin.Molecular and cellular biology · 2000Article
- A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin.Genetics · 1999Article
- Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling.Molecular biology of the cell · 1999Article
- Immunolocalization of beta catenin in intestinal polyps of Peutz-Jeghers and juvenile polyposis syndromes.Journal of clinical pathology · 1999Article
- DE-Cadherin is required for intercellular motility during Drosophila oogenesis.The Journal of cell biology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The armadillo protein of Drosophila and its vertebrate homologues, beta-catenin and plakoglobin, are implicated in cell adhesion and wnt signaling. Here, we examine the conservation of these two functions by assaying the activities of mammalian beta-catenin and plakoglobin in Drosophila. We show that, in the female germ line, both mammalian beta-catenin and plakoglobin complement an armadillo mutation. We also show that shotgun mutant germ cells (which lack Drosophila E-cadherin) have a phenotype identical to that of armadillo mutant germ cells. It therefore appears that armadillo's role in the germ line is solely in a complex with Drosophila E-cadherin (possibly an adhesion complex), and both beta-catenin and plakoglobin can function in Drosophila cadherin complexes. In embryonic signaling assays, we find that plakoglobin has no detectable activity whereas beta-catenin's activity is weak. Surprisingly, when overexpressed, either in embryos or in wing imaginal disks, both beta-catenin and plakoglobin have dominant negative activity on signaling, an effect also obtained with COOH-terminally truncated armadillo. We suggest that the signaling complex, which has been shown by others to comprise armadillo and a member of the lymphocyte enhancer binding factor-1/T cell factor-family, may contain an additional factor that normally binds to the COOH-terminal region of armadillo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.