ArticleThe Biochemical journal1998
Enrichment of carnitine palmitoyltransferases I and II in the contact sites of rat liver mitochondria.
Article in The Biochemical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 65 citations in OpenAlex.
- Personalised modelling of clinical heterogeneity between medium-chain acyl-CoA dehydrogenase patients.BMC biology · 2023Article
- Effects of Copper and/or Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration.International journal of Alzheimer's disease · 2013Article
- L-carnitine is essential to beta-oxidation of quarried fatty acid from mitochondrial membrane by PLA(2).Molecular and cellular biochemistry · 2010Article
- Lipids, mitochondria and cell death: implications in neuro-oncology.Molecular neurobiology · 2010Review
- Structural insight into function and regulation of carnitine palmitoyltransferase.Cellular and molecular life sciences : CMLS · 2009Review
- Self-association of transmembrane domain 2 (TM2), but not TM1, in carnitine palmitoyltransferase 1A: role of GXXXG(A) motifs.The Journal of biological chemistry · 2009Article
- Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV).Biochimica et biophysica acta · 2007Article
- Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity.The Biochemical journal · 2005Article
- Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The liver isoform of carnitine palmitoyltransferase 1 is not targeted to the endoplasmic reticulum.The Biochemical journal · 2003Article
- Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity.The Biochemical journal · 2000Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The submitochondrial distribution of the overt and latent carnitine palmitoyltransferases (CPT I and II respectively) of rat liver mitochondria were studied. Separation of outer and inner membranes, as well as of a fraction of intermediate density consisting of contact sites between the two membranes, was achieved, as judged by the distribution of marker enzymes. Both CPT I and CPT II were found to be enriched within the contact- site fraction of mitochondria. These data show that the two carnitine acyltransferases are distributed non-uniformly within their respective membranes, and that subpopulations of the two enzymes occur in close proximity within the mitochondrial membrane structure, while retaining their different accessibilities to cytosolic and matrix pools of metabolites. As the number of contact sites is known to vary with changes in the energy status of mitochondria, the possibility that such changes may acutely affect the proportion of CPT I within the distinctive lipid environment of the contact sites, and thus its overall kinetic characteristics, is discussed.
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