ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 116 citations in OpenAlex.
- Revitalizing the "biology" in "chronobiology".Npj biological timing and sleep · 2026Review
- CLOCK and TIMELESS regulate rhythmic occupancy of the BRAHMA chromatin-remodeling protein at clock gene promoters.PLoS genetics · 2023Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Social communication activates the circadian gene Tctimeless in Tribolium castaneum.Scientific reports · 2021Article
- Article
- Circadian regulation of metabolism and healthspan in Drosophila.Free radical biology & medicine · 2018Review
- On Variations in the Level of PER in Glial Clocks ofFrontiers in physiology · 2018Article
- SIK3-HDAC4 signaling regulatesProceedings of the National Academy of Sciences of the United States of America · 2017Article
- A new promoter element associated with daily time keeping in Drosophila.Nucleic acids research · 2017Article
- Circadian rhythm in mRNA expression of the glutathione synthesis genePhysiological entomology · 2016Article
- Mammalian retinal Müller cells have circadian clock function.Molecular vision · 2016Article
- Clock and clock-controlled genes are differently expressed in the retina, lamina and in selected cells of the visual system of Drosophila melanogaster.Frontiers in cellular neuroscience · 2015Article
- Casein kinase 1 promotes synchrony of the circadian clock network.Molecular and cellular biology · 2014Article
- Glia-related circadian plasticity in the visual system of Diptera.Frontiers in physiology · 2013Article
- Peripheral circadian rhythms and their regulatory mechanism in insects and some other arthropods: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2012Review
- Effects of aging on the molecular circadian oscillations in Drosophila.Chronobiology international · 2012Article
- Circadian plasticity in photoreceptor cells controls visual coding efficiency in Drosophila melanogaster.PloS one · 2010Article
- Post-translational modifications in circadian rhythms.Trends in biochemical sciences · 2009Review
- Circadian control of dendrite morphology in the visual system of Drosophila melanogaster.PloS one · 2009Article
- CLOCK expression identifies developing circadian oscillator neurons in the brains of Drosophila embryos.BMC neuroscience · 2008Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Circadian oscillations in period (per) mRNA and per protein (PER) constitute, in part, a feedback loop that is required for circadian pacemaker function in Drosophila melanogaster. Oscillations in PER are required for oscillations in per mRNA, but the converse has not been rigorously tested because of a lack of measurable quantities of per mRNA and protein in the same cells. This circadian feedback loop operates synchronously in many neuronal and non-neuronal tissues, including a set of lateral brain neurons (LNs) that mediate rhythms in locomotor activity, but whether a hierarchy among these tissues maintains this synchrony is not known. To determine whether per mRNA cycling is necessary for PER cycling and whether cyclic per gene expression is tissue autonomous, we have generated per01 flies carrying a transgene that constitutively expresses per mRNA specifically in photoreceptors, a cell type that supports feedback loop function. These transformants were tested for different aspects of feedback loop function including per mRNA cycling, PER cycling, and PER nuclear localization. Under both light/dark (LD) cycling and constant dark (DD) conditions, PER abundance cycles in the absence of circadian cycling of per mRNA. These results show that per mRNA cycling is not required for PER cycling and indicate that Drosophila photoreceptors R1-R6 contain a tissue autonomous circadian oscillator.
Indexed as
Identifiers
9425016PMC6792536W2170950314What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.