ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Temporal patterns of gonadotropin-releasing hormone (GnRH), c-fos, and galanin gene expression in GnRH neurons relative to the luteinizing hormone surge in the rat.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Anatomical Markers of Activity in Hypothalamic Neurons.Comprehensive Physiology · 2020Review
- Circadian regulation of membrane physiology in neural oscillators throughout the brain.The European journal of neuroscience · 2020Review
- Gonadal Cycle-Dependent Expression of Genes Encoding Peptide-, Growth Factor-, and Orphan G-Protein-Coupled Receptors in Gonadotropin- Releasing Hormone Neurons of Mice.Frontiers in molecular neuroscience · 2020Article
- Proestrus Differentially Regulates Expression of Ion Channel and Calcium Homeostasis Genes in GnRH Neurons of Mice.Frontiers in molecular neuroscience · 2019Article
- Sex Differences in Steroid Receptor Coexpression and Circadian-Timed Activation of Kisspeptin and RFRP-3 Neurons May Contribute to the Sexually Dimorphic Basis of the LH Surge.Endocrinology · 2017Article
- Altered Expression of Genes Encoding Neurotransmitter Receptors in GnRH Neurons of Proestrous Mice.Frontiers in cellular neuroscience · 2016Article
- Vasoactive intestinal peptide modulation of the steroid-induced LH surge involves kisspeptin signaling in young but not in middle-aged female rats.Endocrinology · 2014Article
- Examination of the influence of leptin and acute metabolic challenge on RFRP-3 neurons of mice in development and adulthood.Neuroendocrinology · 2014Article
- Kisspeptin neurones do not directly signal to RFRP-3 neurones but RFRP-3 may directly modulate a subset of hypothalamic kisspeptin cells in mice.Journal of neuroendocrinology · 2013Article
- Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus.Endocrinology · 2012Article
- Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling.Endocrinology · 2012Article
- Influence of ERβ selective agonism during the neonatal period on the sexual differentiation of the rat hypothalamic-pituitary-gonadal (HPG) axis.Biology of sex differences · 2012Article
- Endocrine disruption of brain sexual differentiation by developmental PCB exposure.Endocrinology · 2011Article
- Interactions between neurotensin and GnRH neurons in the positive feedback control of GnRH/LH secretion in the mouse.American journal of physiology. Endocrinology and metabolism · 2010Article
- Neonatal bisphenol-a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons.Biology of reproduction · 2009Article
- Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge.Endocrinology · 2009Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Gonadotropin-releasing hormone (GnRH) neurons increase their expression of Fos and galanin coincident with the luteinizing hormone (LH) surge in the female rat. To define the temporal relationships between the expression of these genes and the GnRH gene itself and to gain insight about the possible functional interactions of these processes, we compared levels of c-fos, galanin, and GnRH mRNA in GnRH neurons and plasma levels of LH in the rat, beginning 6 hr before and continuing for 24 hr after a sex steroid-induced LH surge. LH levels were increased significantly by 1600 hr. They increased twofold further by 1800 hr and then returned to baseline by 2400 hr. Using in situ hybridization, we determined that levels of c-fos mRNA in GnRH neurons were elevated significantly at 1600 hr only, whereas levels of galanin mRNA in GnRH neurons first increased twofold by 1800 hr, increased an additional twofold by 2400 hr, and remained elevated at all time points sampled thereafter. There were no significant changes in cellular levels of GnRH mRNA over the time points sampled. These results are consistent with the hypothesis that the induction of c-fos gene expression in GnRH neurons leads to an increase in galanin gene expression, and that the sustained increase in galanin mRNA levels in GnRH neurons reflects either the need to replenish galanin stores that are depleted at the time of the LH surge or the involvement of galanin with physiological events that occur on the day of estrus.
Indexed as
Identifiers
9425013PMC6792541W2132792673What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.