ArticleJournal of bacteriology1998
Identification and characterization of aarF, a locus required for production of ubiquinone in Providencia stuartii and Escherichia coli and for expression of 2'-N-acetyltransferase in P. stuartii.
Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 75 citations in OpenAlex.
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- The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria.Journal of cell science · 2023Article
- Genome-scale analysis of Arabidopsis splicing-related protein kinase families reveals roles in abiotic stress adaptation.BMC plant biology · 2022Article
- Identification and Characterization of a Novel Chromosomal Aminoglycoside 2'-Frontiers in microbiology · 2021Article
- In silico characterization of a novel putative aerotaxis chemosensory system in the myxobacterium, Corallococcus coralloides.BMC genomics · 2018Article
- Balanced CoQMicrobial cell (Graz, Austria) · 2017Article
- The Role of the Atypical Kinases ABC1K7 and ABC1K8 in Abscisic Acid Responses.Frontiers in plant science · 2016Article
- Sponge Microbiota Are a Reservoir of Functional Antibiotic Resistance Genes.Frontiers in microbiology · 2016Article
- Mining microbial metatranscriptomes for expression of antibiotic resistance genes under natural conditions.Scientific reports · 2015Article
- Loss of plastoglobule kinases ABC1K1 and ABC1K3 causes conditional degreening, modified prenyl-lipids, and recruitment of the jasmonic acid pathway.The Plant cell · 2013Article
- Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants.Biochimica et biophysica acta · 2011Article
- AtOSA1, a member of the Abc1-like family, as a new factor in cadmium and oxidative stress response.Plant physiology · 2008Article
- ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency.American journal of human genetics · 2008Article
- CABC1 gene mutations cause ubiquinone deficiency with cerebellar ataxia and seizures.American journal of human genetics · 2008Article
- Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans.Molecular and cellular biology · 2006Article
- The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum.Genome biology · 2005Article
- Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis.Journal of bacteriology · 2000Article
- Linkage map of Escherichia coli K-12, edition 10: the traditional map.Microbiology and molecular biology reviews : MMBR · 1998Review
- Overlapping functions of components of a bacterial Sec-independent protein export pathway.The EMBO journal · 1998Article
- Mutations in aarE, the ubiA homolog of Providencia stuartii, result in high-level aminoglycoside resistance and reduced expression of the chromosomal aminoglycoside 2'-N-acetyltransferase.Antimicrobial agents and chemotherapy · 1998Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Providencia stuartii contains a chromosomal 2'-N-acetyltransferase [AAC(2')-Ia] involved in the O acetylation of peptidoglycan. The AAC(2')-Ia enzyme is also capable of acetylating and inactivating certain aminoglycosides and confers high-level resistance to these antibiotics when overexpressed. We report the identification of a locus in P. stuartii, designated aarF, that is required for the expression of AAC(2')-Ia. Northern (RNA) analysis demonstrated that aac(2')-Ia mRNA levels were dramatically decreased in a P. stuartii strain carrying an aarF::Cm disruption. The aarF::Cm disruption also resulted in a deficiency in the respiratory cofactor ubiquinone. The aarF locus encoded a protein that had a predicted molecular mass of 62,559 Da and that exhibited extensive amino acid similarity to the products of two adjacent open reading frames of unknown function (YigQ and YigR), located at 86 min on the Escherichia coli chromosome. An E. coli yigR::Kan mutant was also deficient in ubiquinone content. Complementation studies demonstrated that the aarF and the E. coli yigQR loci were functionally equivalent. The aarF or yigQR genes were unable to complement ubiD and ubiE mutations that are also present at 86 min on the E. coli chromosome. This result indicates that aarF (yigQR) represents a novel locus for ubiquinone production and reveals a previously unreported connection between ubiquinone biosynthesis and the regulation of gene expression.
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