ArticleNucleic acids research1998
Cys2/His2 zinc-finger protein family of petunia: evolution and general mechanism of target-sequence recognition.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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75 citing papers in PubMed, 160 citations in OpenAlex.
- Genome-wide identification and characterization of theFrontiers in plant science · 2026Article
- Functional characterization of four soybean C2H2 zinc-finger genes inPlant signaling & behavior · 2025Article
- C2H2 Zinc Finger Proteins GIS2 and ZFP8 Regulate Trichome Development via Hormone Signaling in Arabidopsis.International journal of molecular sciences · 2025Article
- Identification of the Q-type ZFP gene family in Triticeaes and drought stress expression analysis in common wheat.Genetica · 2025Article
- PpBBX32 and PpZAT5 modulate temperature-dependent and tissue-specific anthocyanin accumulation in peach fruit.Horticulture research · 2024Article
- Characterization of the ZCTs, a subgroup of Cys2-His2 zinc finger transcription factors regulating alkaloid biosynthesis in Catharanthus roseus.Plant cell reports · 2024Article
- Transcriptomic Identification of Potential C2H2 Zinc Finger Protein Transcription Factors inInternational journal of molecular sciences · 2024Article
- Genome-wide identification of the Q-type C2H2 zinc finger protein gene family and expression analysis under abiotic stress in lotus (Nelumbo nucifera G.).BMC genomics · 2024Article
- Wheat zinc finger protein TaZF interacts with both the powdery mildew AvrPm2 protein and the corresponding wheat Pm2a immune receptor.Plant communications · 2024Article
- Molecular Evolution of RAMOSA1 (RA1) in Land Plants.Biomolecules · 2024Article
- Genome-wide analysis of the C2H2-ZFP gene family in Stevia rebaudiana reveals involvement in abiotic stress response.Scientific reports · 2024Article
- Genome-wide identification and expression analysis of C2H2 zinc finger proteins in Chinese jujube (PeerJ · 2024Article
- Genome-Wide Identification and Analysis of the Genes Encoding Q-Type C2H2 Zinc Finger Proteins in Grapevine.International journal of molecular sciences · 2023Article
- Genome-Wide Analysis of Q-Type C2H2 ZFP Genes in Response to Biotic and Abiotic Stresses in Sugar Beet.Biology · 2023Article
- Genome-Wide Analysis ofPlants (Basel, Switzerland) · 2023Article
- Article
- Function and Evolution of C1-2i Subclass of C2H2-Type Zinc Finger Transcription Factors in POPLAR.Genes · 2022Article
- Genome-wide analysis of the C2H2 zinc finger protein gene family and its response to salt stress in ginseng, Panax ginseng Meyer.Scientific reports · 2022Article
- C2H2 Zinc Finger Proteins Response to Abiotic Stress in Plants.International journal of molecular sciences · 2022Review
- PpZAT5 suppresses the expression of a B-box geneFrontiers in plant science · 2022Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The EPF family is a group of Cys2/His2zinc-finger proteins in petunia. In these proteins, characteristically long spacer regions have been found to separate the zinc fingers. Our previous DNA-binding studies demonstrated that two-fingered proteins (ZPT2-1 and ZPT2-2), which have spacers of different lengths, bind to two separate AGT core motifs in a spacing specific manner. To investigate the possibility that these proteins might distinguish between the target sequences on the basis of spacing between the core motifs, we screened petunia cDNA library for other proteins belonging to this family. Initial screening by PCR and subsequent cloning of full-length cDNAs allowed us to identify the genes for 10 new proteins that had two, three or four zinc fingers. Among the two-fingered proteins the spacing between zinc fingers varied from 19 to 65 amino acids. The variation in the length of spacers was even more extensive in three- and four-fingered proteins. The presence of such proteins is consistent with our hypothesis that the spacing between the core motifs might be important for target sequence recognition. Furthermore, comparison of diverse protein structures suggests that three- and two-fingered proteins might have resulted due to successive loss of fingers from a four-fingered protein during molecular evolution. We also demonstrate that a highly conserved motif (QALGGH) among the members of EPF family and other Cys2/His2 zinc-finger proteins in plants is critical for the DNA-binding activity.
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