ArticleJournal of virology1998
Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 75 citations in OpenAlex.
- Comparative structural studies on Bovine papillomavirus E6 oncoproteins: Novel insights into viral infection and cell transformation from homology modeling and molecular dynamics simulations.Genetics and molecular biology · 2024Article
- An Update on African Swine Fever Virology.Viruses · 2019Review
- Proteomic analysis of the gamma human papillomavirus type 197 E6 and E7 associated cellular proteins.Virology · 2017Article
- Mutagenic Potential ofBos taurus Papillomavirus Type 1 E6 Recombinant Protein: First Description.BioMed research international · 2015Article
- Article
- The role of ubiquitin and ubiquitin-like modification systems in papillomavirus biology.Viruses · 2014Review
- Interactions between E6, FAK, and GIT1 at paxillin LD4 are necessary for transformation by bovine papillomavirus 1 E6.Journal of virology · 2014Article
- Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic.Immunologic research · 2014Review
- Papillomavirus E6 oncoproteins.Virology · 2013Review
- Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling.Oncogene · 2012Article
- Strategies for bacterial expression of protein-peptide complexes: application to solubilization of papillomavirus E6.Protein expression and purification · 2011Article
- E6 proteins from diverse papillomaviruses self-associate both in vitro and in vivo.Journal of molecular biology · 2010Article
- Bovine papillomavirus E7 oncoprotein inhibits anoikis.Journal of virology · 2007Article
- p600, a unique protein required for membrane morphogenesis and cell survival.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Bovine papillomavirus E7 transformation function correlates with cellular p600 protein binding.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Opposing effects of bovine papillomavirus type 1 E6 and E7 genes on Fas-mediated apoptosis.Oncogene · 2005Article
- Hepatitis B virus large envelope protein interacts with gamma2-adaptin, a clathrin adaptor-related protein.Journal of virology · 2001Article
- Interaction of human immunodeficiency virus type 2 Vpx and invariant chain.Journal of virology · 2000Article
- The bovine papillomavirus type 1 E6 oncoprotein sensitizes cells to tumor necrosis factor alpha-induced apoptosis.Oncogene · 1999Article
- Papillomaviruses: a systematic review.Genetics and molecular biologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The E6 gene of the bovine papillomavirus type 1 (BPV-1) is expressed in fibropapillomas caused by BPV-1 and in tissue culture cells transformed by BPV-1. It encodes one of the two major oncoproteins of BPV-1. In this study, we demonstrate an interaction between the BPV-1 E6 protein and AP-1, the TGN (trans-Golgi network)-specific clathrin adaptor complex. AP-1 is a four-subunit protein complex required for clathrin-mediated cellular transport from the TGN. The AP-1/E6 interaction was observed in vitro and in cells. The E6 binding site on AP-1 was mapped to the N-terminal trunk domain of the gamma subunit. BPV-1 E6 preferentially associated with membrane-bound AP-1 in cells but not with free cytosolic AP-1. BPV-1 E6 was further shown to be recruited to isolated Golgi membranes and to copurify with clathrin-coated vesicles. The recruitment of BPV-1 E6 to Golgi membranes was AP-1 independent, but the E6 interaction with AP-1 was required for its association with clathrin-coated vesicles. Furthermore, AP-1 proteins could compete with BPV-1 E6 for binding to Golgi membranes, suggesting that the recruitment of BPV-1 E6 and AP-1 to Golgi membranes involves a common factor. Taken together, our results suggest that cytosolic BPV-1 E6 is first recruited to the TGN, where it is then recognized by membrane-bound AP-1 and subsequently recruited into TGN-derived clathrin-coated vesicles. We propose that BPV-1 E6, through its interaction with AP-1, can affect cellular processes involving clathrin-mediated trafficking pathway.
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