ArticleJournal of virology1998
Cells with high cyclophilin A content support replication of human immunodeficiency virus type 1 Gag mutants with decreased ability to incorporate cyclophilin A.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Cyclophilin A facilitates HIV-1 integration.Journal of virology · 2024Article
- Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus.Journal of virology · 2023Review
- HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules.Retrovirology · 2021Review
- Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity.Journal of virology · 2019Article
- A restriction enzyme based cloning method to assess the in vitro replication capacity of HIV-1 subtype C Gag-MJ4 chimeric viruses.Journal of visualized experiments : JoVE · 2014Article
- Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication.Retrovirology · 2012Article
- SIV replication in human cells.Frontiers in microbiology · 2012Article
- Cyclophilin A restricts influenza A virus replication through degradation of the M1 protein.PloS one · 2012Article
- Article
- Strain-specific differences in the impact of human TRIM5alpha, different TRIM5alpha alleles, and the inhibition of capsid-cyclophilin A interactions on the infectivity of HIV-1.Journal of virology · 2010Article
- Target cell type-dependent modulation of human immunodeficiency virus type 1 capsid disassembly by cyclophilin A.Journal of virology · 2009Article
- Modulation of HIV-1 infectivity and cyclophilin A-dependence by Gag sequence and target cell type.Retrovirology · 2009Article
- Analysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant.Journal of virology · 2007Article
- Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.Journal of virology · 2007Article
- Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.Journal of virology · 2007Article
- Vif counteracts a cyclophilin A-imposed inhibition of simian immunodeficiency viruses in human cells.Journal of virology · 2007Article
- A molecular dynamics study of Cyclophilin A free and in complex with the Ala-Pro dipeptide.European biophysics journal : EBJ · 2007Article
- The cysteine residues of HIV-1 capsid regulate oligomerization and cyclophilin A-induced changes.Biophysical journal · 2005Article
- Virus particle core defects caused by mutations in the human immunodeficiency virus capsid N-terminal domain.Journal of virology · 2005Article
- Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.Journal of virology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Gag polyprotein-mediated incorporation of cellular cyclophilin A (CyPA) into virions is essential for the formation of infectious human immunodeficiency virus type 1 (HIV-1) virions. Either a point mutation in Gag (P222A) or drugs which bind CyPA decrease virion incorporation of CyPA and interfere with HIV-1 replication. We have found that lymphoid cells varied greatly in their CyPA content and that cells with high CyPA content supported the replication of P222A HIV-1 Gag mutants. These experiments demonstrated that a higher cellular CyPA content of some cells was able to compensate for the decreased binding affinity of P222A mutant Gag for CyPA, allowing virus replication to occur.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.