ArticleProceedings of the National Academy of Sciences of the United States of America1998
Universally conserved translation initiation factors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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94 citing papers in PubMed, 246 citations in OpenAlex.
- A Microscale Platform for the Comprehensive Analysis of Bacterial Translation Initiation.International journal of molecular sciences · 2026Article
- Pleiotropic roles of elongation factor P inMicrobiology spectrum · 2026Article
- Article
- Asgard archaea: have we found our microbial ancestors?The EMBO journal · 2026Review
- Expression of translation elongation factor P in Kocuria rhizophila is regulated by an inducible weak promoter.BMC microbiology · 2026Article
- Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life.bioRxiv : the preprint server for biology · 2025Article
- The origins and evolution of translation factors.Trends in genetics : TIG · 2025Review
- Structures of Saccharolobus solfataricus initiation complexes with leaderless mRNAs highlight archaeal features and eukaryotic proximity.Nature communications · 2025Article
- Expression of Staphylococcus aureus translation elongation factor P is regulated by a stress-inducible promotor.Antonie van Leeuwenhoek · 2024Article
- Contribution of tRNA sequence and modifications to the decoding preferences of E. coli and M. mycoides tRNAGlyUCC for synonymous glycine codons.Nucleic acids research · 2024Article
- Article
- Article
- Role of aIF5B in archaeal translation initiation.Nucleic acids research · 2022Article
- Functions and Regulation of Translation Elongation Factors.Frontiers in molecular biosciences · 2021Review
- Programmed Deviations of Ribosomes From Standard Decoding in Archaea.Frontiers in microbiology · 2021Review
- A translational program that suppresses metabolism to shield the genome.Nature communications · 2020Article
- Article
- Translation elongation factor P (EF-P).FEMS microbiology reviews · 2020Review
- Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation.Communications biology · 2020Article
- Insights Into the Binding Mechanism of GC7 to Deoxyhypusine Synthase inFrontiers in chemistry · 2020Article
34 more citing papers are in PubMed but not listed here.
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The process by which translation is initiated has long been considered similar in Bacteria and Eukarya but accomplished by a different unrelated set of factors in the two cases. This not only implies separate evolutionary histories for the two but also implies that at the universal ancestor stage, a translation initiation mechanism either did not exist or was of a different nature than the extant processes. We demonstrate herein that (i) the "analogous" translation initiation factors IF-1 and eIF-1A are actually related in sequence, (ii) the "eukaryotic" translation factor SUI1 is universal in distribution, and (iii) the eukaryotic/archaeal translation factor eIF-5A is homologous to the bacterial translation factor EF-P. Thus, the rudiments of translation initiation would seem to have been present in the universal ancestor stage. However, significant development and refinement subsequently occurred independently on both the bacterial lineage and on the archaeal/eukaryotic line.
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