ArticleProceedings of the National Academy of Sciences of the United States of America1998
Nitric oxide and thiol redox regulation of Janus kinase activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 148 citations in OpenAlex.
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- Ruxolitinib Reduces Oxidative Stress in Patients With Primary Myelofibrosis: A Multicenter Study.Cureus · 2022Article
- Heat stress modulates polymorphonuclear cell response in early pregnancy cows: I. interferon pathway and oxidative stress.PloS one · 2021Article
- The Role of Reactive Oxygen Species in Acute Myeloid Leukaemia.International journal of molecular sciences · 2019Review
- The Cooperative Relationship between STAT5 and Reactive Oxygen Species in Leukemia: Mechanism and Therapeutic Potential.Cancers · 2018Review
- The value of Nigella sativa in the treatment of experimentally induced rhinosinusitis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2017Article
- Article
- The immunobiology of myeloid-derived suppressor cells in cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Dynamic Redox Regulation of IL-4 Signaling.PLoS computational biology · 2015Article
- Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells.Acta pharmacologica Sinica · 2015Article
- The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function.Frontiers in physiology · 2015Review
- FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis.American journal of hematology · 2014Article
- Thiol-based redox proteins in abscisic acid and methyl jasmonate signaling in Brassica napus guard cells.The Plant journal : for cell and molecular biology · 2014Article
- 2-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinase.Cancer science · 2014Article
- Article
- Myeloid derived suppressor cells in physiological and pathological conditions: the good, the bad, and the ugly.Immunologic research · 2013Review
- Redox regulation of Janus kinase: The elephant in the room.JAK-STAT · 2013Review
- Article
- Identification of a redox-sensitive switch within the JAK2 catalytic domain.Free radical biology & medicine · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The activation of Janus kinases (JAKs) is crucial for propagation of the proliferative response initiated by many cytokines. The proliferation of various cell lines, particularly those of hematopoietic origin, is also modulated by mediators of oxidative stress such as nitric oxide and thiol redox reagents. Herein we demonstrate that nitric oxide and other thiol oxidants can inhibit the autokinase activity of rat JAK2 in vitro, presumably through oxidation of crucial dithiols to disulfides within JAK2. The reduced form of JAK2 is the most active form, and the oxidized JAK2 form is inactive. Nitric oxide pretreatment of quiescent Ba/F3 cells also inhibits the interleukin 3-triggered in vivo activation of JAK2, a phenomenon that correlates with inhibited proliferation. Furthermore, we observed that the autokinase activity of JAK3 responds in a similar fashion to thiol redox reagents in vitro and to nitric oxide donors in vivo. We suggest that the thiol redox regulation of JAKs may partially explain the generally immunosuppressive effects of nitric oxide and of other thiol oxidants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.