ArticleThe Journal of experimental medicine1998
The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Early events in TCR signaling - the evolving role of ITAMs.Frontiers in immunology · 2025Review
- Defective LAT signalosome pathology in mice mimics human IgG4-related disease at single-cell level.The Journal of experimental medicine · 2023Article
- Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- TCR beta feedback signals inhibit the coupling of recombinationally accessible V beta 14 segments with DJ beta complexes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Constitutive endocytosis and degradation of the pre-T cell receptor.The Journal of experimental medicine · 2002Article
- Characterization of T cell differentiation in the murine gut.The Journal of experimental medicine · 2002Article
- An endoplasmic reticulum retention function for the cytoplasmic tail of the human pre-T cell receptor (TCR) alpha chain: potential role in the regulation of cell surface pre-TCR expression levels.The Journal of experimental medicine · 2001Article
- Function of CD3 epsilon-mediated signals in T cell development.The Journal of experimental medicine · 2000Article
- Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice.The EMBO journal · 2000Article
- Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.The Journal of experimental medicine · 1999Article
- Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein.The Journal of experimental medicine · 1999Article
- Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex.The Journal of experimental medicine · 1999Article
- Regulation of T cell receptor (TCR) beta gene expression by CD3 complex signaling in immature thymocytes: implications for TCRbeta allelic exclusion.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pre-T cell receptor (TCR) associates with CD3-transducing subunits and triggers the selective expansion and maturation of T cell precursors expressing a TCR-beta chain. Recent experiments in pre-Talpha chain-deficient mice have suggested that the pre-TCR may not be required for signaling allelic exclusion at the TCR-beta locus. Using CD3-epsilon- and CD3-zeta/eta-deficient mice harboring a productively rearranged TCR-beta transgene, we showed that the CD3-gammadeltaepsilon and CD3-zeta/eta modules, and by inference the pre-TCR/CD3 complex, are each essential for the establishment of allelic exclusion at the endogenous TCR-beta locus. Furthermore, using mutant mice lacking both the CD3-epsilon and CD3-zeta/eta genes, we established that the CD3 gene products are dispensable for the onset of V to (D)J recombination (V, variable; D, diversity; J, joining) at the TCR-beta, TCR-gamma, and TCR-delta loci. Thus, the CD3 components are differentially involved in the sequential events that make the TCR-beta locus first accessible to, and later insulated from, the action of the V(D)J recombinase.
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